Endocrinology Flashcards
What hormones is most concered with the regulation of body fluid?
Where is this hormone made?
ADH
Hypothalamus: Supraoptic nucleus
Which of the followingwould trigger the release of ADH? Bonus: change the incorrect ones so that they’re all correct
A. Increase in BP
B. Increase in blood volume
C. Increase in osmolality
D. decrease in angiotensin II
Increase in osmolality
- Decrease BP*
- Decrease in blood volume*
- Increase in angiotensin II*
Which of the following receptors does ADH target to increase water reabsorption by the kidneys?
A. V1
B. V2
C. alpha-1
D. Beta-1
V2
T/F: ADH makes you thirsty
True
Which of the following is true under conditions of hypoosmolality?
A.Increased release of ADH
B. Reabsorption of water
C. Urine becomes more dilute
D. None of the above
Urine becomes more dilute
- we decrease the amount of ADH released, remove more water from the blood and see a more dilute urine
Which of the following disorders causes a lack of effect of ADH on the collecting duct?
A. Central Diabetes Insipidus
B. Peripheral Diabietes Insipidus
C. Nephrogenic Diabetes Insipidus
D. SIADH
Nephrogenic Diabetes Insipidus
In which of the following disorders do you see an increase in ADH and water retention, even during periods of hypoosmolality?
A. Central Diabetes Insipidus
B. Peripheral Diabietes Insipidus
C. Nephrogenic Diabetes Insipidus
D. SIADH
SIADH
What are the affects of aldosterone on potassium?
K+ secretion
A decrease in mean arterial pressure would be addressed by the release of ______
Renin
Which of the following describes what one might see in a primary adrenal insufficiency?
A. Both cortisol and aldosterone levels are decreased despite high levels of renin
B. Decrease in cortisol but normal levels of aldosterone and renin
C. Both cortisol and aldosterone levels are increased while renin is decreased
D. All of the above are made up
Both cortisol and aldosterone levels are decreased despite high levels of renin
Where would we find BNP?
What is the affect of this peptide?
VEntricular myocytes
Decrease NaCl and water reabsorption by the collecting duct
Urodilatin and ANP are encoded by the same gene, but differ in where they are secreted. Where is urodilatin secreted, and what is its mechanistic goal?
Distal Tubule and Collecting Duct
Inhibits NaCl and water reabsorption across the medullary portion of the collecting duct
All of the following is true of the actions of ANP, except?
A. inhibit renin, aldosteron, and ADH secretion
B. Vasoconstriction of afferents and vasodilation of efferents
C. Increase GFR and filtered NaCl
D. Vasodilation of afferents and vasoconstriction of efferents
Vasodilation of afferents and vasoconstriction of efferents
Release of which of the following from sympathetic nerves stimulate reabsorption of NaCl in all of the following locations, EXCEPT?
A. Proximal Tubule
C. Thin ascending limb
D. Thick ascending limb
E. Distal Tubule
F. Collecting Duct
Thin ascending limb
Select all of the scenarios that are true regarding effectively decreasing Na+ reabsorption at the collecting duct or proximal tubule.
A. Decrease of sympathetic activity causes dilation of afferent arterioles increasing GFR
B. Increase in ANP which will constrict efferent arterioles and increase GFR
C. Decrease in osmotic capillary pressure
D. Decrease in RAAS
E. All of the above are correct
All of the above are correct