Endocrine- Steroid Hormones Flashcards
steroid hormones are ???-soluble because they are made from ???
lipid soluble
made from cholesterol
steroid hormones are synthesised in the ??? cortex (cortisol, aldosterone) and Gonads (oestrogen, progesterone, testosterone)
adrenal cortex
are steroid hormones synthesised on demand and not stored?
yes
TRUE or FALSE: steroid hormone synthesis is controlled by hormones from the ??? gland and hypothalamus
pituitary gland
synthesis is frmo a cholesterol precursor where 80% is made in the ??? as VLDL and 20% from scratch from acetyl CoA
liver
steroid hormones secreted out of ???/??? and diffuse through cell membranes
adrenal gland/gonads
transport of steroid hormones is in the blood, bound to ??? eg albumin
transport proteins
steroid hormones are metabolised (broken down) in liver to bile acids and removed through ???
urinary excretion
Steroid hormone receptors are nuclear or ??? cytoplasmic receptors
intracellular cytoplasmic receptors
Steroid hormone receptors are ligand-??? transcription factors, meaning they link extracellular signals to gene transcription
ligand-activated transcription factors
steroid hormone cytoplasmic receptors are complexed to ??? proteins
chaperone proteins
the binding of steroid hormones to chaperone/receptor complex causes ??? change. Once chaperone dissociates from ligand/receptor complex, this complex becomes an active transcription factor
conformational change
Nuclear receptors act in the same way as cytoplasmic receptors but are located in the ???
nucleus
steroid hormone receptors bind to a specific site on ??? which is determined by receptor type. this regulates which genes will be transcribed
DNA
what regulates which genes will be transcribed?
the specific binding receptor for steroid hormones
