Endocrine- Hormone actions, regulation, clearance Flashcards
Partial agonist: binds to receptor, partially activating cell ??? pathways for a partial effect
partially activating cell signalling pathways
antagonist amines: binds/blocks receptor, blocking cell ??? for no effect
cell signalling transduction
agonist amines: bind to ??? and activate cell signal transduction for an effect
receptor
constitutive activity: receptors have basal level of activity independant or dependant of ligand?
independant
complementary action: several hormones contribute to ??? eg epinephrine and glucagon during exercise
physiological function
TRUE or FALSE: Cells can modify their sensitivity to a given hormone by increasing or decreasing their receptor populations = homeostasis
TRUE
upregulation is when a cell increases number of ??? which can occur is insufficient ??? available or if cell requires greater effect
receptors
ligand
an example of ??? is uterine oxytocine receptors in pregnancy
upregulation
Downregulaiton is when cell decreases number of receptors which can occur if too much ??? available
ligand
TRUE or FALSE: enzymes can be degraded in target cells, at the receptor, or by releasing out of cell
TRUE
when hormones are bound, their half life is ??? by half its original concentration
extended
hormones that bind to proteins are cleared from the blood very ???
slowly
Immunoassay for hormonal measurements include ELISA (works like a ??? where final step is to measure colour change with spectrophotometry) and RIA (radioimmunosorbent assay using a radioactive antibody)
sandwich
response to hormone can be regulated by the action of the ??? (eg, agonist, antagonist, partial agonist etc)
receptor
response to hormone can be regulated by the density or ??? (eg up/down regulation)
density of receptors
