Endocrine Pearls (Thyroid, Pituitary, Adrenals) Flashcards
What is the number one cause of Hyperthyroidism?
Multinodular goiter (Grave’s disease)
How does PTU work?
decreases hormone synthesis, it also decreases peripheral conversion of T4 to T3. Takes several weeks
How does methimazole work?
It also decreases thyroid hormone synthesis, but does NOT have the added benefit of decreasing conversion .
Anesthetic concerns for hyperthyroid patients;
d/t potential preoperative morbidity assoc with thyroid storm, patients should be made euthyroid before proceeding with elective cases
Ddx for stridor:
hematoma, b/l recurrent laryngeal nerve injury, and laryngospasm due to hypocalcemia
What does the RLN supply: B/l vs unilateral RLN injury
motor innervation to all the intrinsic muscles of the larynx EXCEPT the cricothyroid (superior laryngeal nerve) .
RLN injury allows for unopposed action of cricothyroid muscles (vocal cord tensors) causing airway obstruction. Unilateral injury usually results in hoarseness.
Which nerve innervates the cricothyroid?
Superior laryngeal nerve
How can you determine whether hypocalcemia is the cause of stridor? If it is, what can you do to fix it?
Ca2+ could be drawn, but hypocalcemia is rare before 12 hours post op. Paresthesias, cramps, and facial nerve excitability (Chvostek’s sign). You can give calcium chloride
Signs of hyperthyroidism:
tachycardia, weight loss, diarrhea, atrial fib
What can precipitate thyroid storm, and when does it happen (usually)
Precipitated by stress, infection, or surgery. Usually happens post op. Use propranolol in emergencies
Intraop in hyperthyroidism:
Try to avoid sympathomimetics
What does PTH do?
bone resorption, renal distal tubular resorption (also absorbs Mg2+, excretes HCO3-, PO4-), synthesizes 1,25 Dihydroxyvitamin d
How does calcium exist? If serum proteins, phosphate, and acidosis increase, what happens to calcium?
50% of serum calcium is ionized, 40% is bound to protein (mainly albumin), 10% to anions.
If those things happen, ionized calcium will decrease. Acidosis decreases protein binding, so more of it becomes free (so free calcium increases with acidosis), but acidosis decreases the calcium that is ionized. Got it.
Low phosphate can cause:
hemolysis, platelet dysfunction and impaired myocardial contractility leading to CHF
The deeper you go, the sweeter it gets. Explain the Adrenal cortex:
Mineralocorticioids
Glucocrticoids
Androgens