Endocrine dysfunction Flashcards
How can endocrine diseases arise?
Hormones are either over or under produced, receptors can malfunction,
What is a primary endocrine disease?
problems caused by the endocrine gland itself
What is a secondary endocrine disease?
caused by a problem outside of the endocrine system
What is Hyperadrenocorticism?
excessive levels of cortisol being produced
What are the two major components of Hyperadrenocorticism?
Pituitary dependent and adrenal dependent
What are some of the main functions of cortisol?
stimulatory effects on gluconeogenesis, lipolysis, osteoclast activity
What is Hypoadrenocorticism?
immune mediated destruction of the adrenal glands which leads to less mineralcorticoid and glucocorticoid production
What is hyperparathyroidism?
Due to an overactive parathyroid, leads to an over production of PTH
What is Lymphocytic parathyroiditis?
chief cells of gland degenerate and are replaced by connective tissues.
What is Panhypopituitarism?
A generalised reduction in pituitary hormone
What species is cushings disease most common in?
adult dogs
What are some clinical signs of cushings disease?
Muscle weakness, Pot-belly, Obesity, Alopecia
What species of animal is hypoadrenocorticism most common in?
Dogs and ocassionally horses
What are some of the symptoms of addisons disease?
Progressive loss of body condition, Vomiting, bradycardia/ weakness
What happens when you inject glucocorticoids?
Clinical signs of hyperadrenocorticism (high cortisol levels)
causes the glands to atrophy
They no longer produce cortisol
If you then abrubtly stop injecting glucocorticoids
hypoadrenocorticism occurs
