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Pharmacology > Endocrine Drugs > Flashcards

Endocrine Drugs Flashcards

0
Q

Posterior pituitary

A

Neurohypophysis

Storage vesicle

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1
Q

Anteriorp ituitary functions

A

Adenohypophysis

Secretion of releasing and inhibiting hormones

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2
Q

Moa endocrine

A

Binds to plasma membrane

To intracellular receptors- cytoplasmic and nuclear

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3
Q

Growth hormone moa

A

Stimulates liver to produce somatomedins
Produces growth at open epiphyses via IGF1
Children- linear growth of skel muscle
Adult- anabolic effect

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4
Q

GH indications

A

Hypopituitary dwarfism

Non gh deficient short child

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5
Q

Toxicity gh

A

CJD

Problems in hip, knee, spine

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6
Q

Pegvisomant- gh antag

A

Acromegaly, excessive gh

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7
Q

Somatomedin c

A

Igf-1

For growth failure due to igf1 deficiency

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8
Q

Somatostatin

A

Blocks gh, tsh, insulin, glucagon

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9
Q

Indications of somatostatin analogs

A

Acromegaly
Tsh secreting pituitary adenomas
Carcinoid tumors
VIP secreting tumors

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10
Q

What is trh for

A

Diagnostics

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11
Q

Thyrotropin alfa

A

Stimulate RAI by metastatic thyroid ca

Im, sq

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12
Q

Corticotropin releaing hormone

A

Diagnostic!
Diff cushings from ectopic acth
Cushing inc acth

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13
Q

Acth

A

Diagnostic

Tetracosactide

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14
Q

Therapeutic goal of gnrh agonist

A

Reversible hypogonadism

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15
Q

Indications gnrh agonist

A

Med menopause
Female disorders dept on estrogen(endometriosis)
Ivf therapy
Delay puberty in indiv with precocious puberty

16
Q

Side effects gnrh

A

Hot flushes

Osteoporosis

17
Q

Gnrh antag

A

Blocks receptors
No flare effect
Prevention of endogenous ovulation

18
Q

Abarelix

A

Palliative treatment of adv symptomatic prostate ca

19
Q

Cetrorelix and ganirelix

A

Inhibition of premature lh surges

20
Q

Fsh

A

Women- follicular devt, androgen to estrogen, twins

Men- spermatogenesis, production of abp

21
Q

Highly purified prep of human fsh from urine of post mens

A

Urofollitropin

22
Q

Follitropin alfa and beta

A

No lh activity

23
Q

Lh

A

Induce ovulation

Lutropin alfa- only source of pure lh

24
Q

Dopamine agonist

A

Prl secreting adenomas
Amenorrhea-galactorrhea
Acromegaly

25
Q

Cabergoline

A

Ergot
Agonist for d2 receptor
First line for prolactinomas

26
Q

Oxytocin

A

Iv, inactivated orally

Produce sustained uterine contraction

27
Q

Oxytocin effects can be inhibited by

A

Beta agonist- terbutaline, isoxsuprine
Mgso4
Inhalational anesthetic agents

28
Q

Oxytocin indications

A

Contraction stress test

Induction and augmentation of labor

29
Q

Oxytocin agonist

A

Carbetocin- control of postpartum bleeding

demoxytocin- prevention puerperal mastitis

30
Q

Vasopressin

A

Deficiency state- diabetes insipidus

Iv, im, intra nasal

Pharmacology (15 decks)

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