Endocrine Drugs

Question 0

Posterior pituitary

Answer 0

Neurohypophysis

Storage vesicle

Question 1

Anteriorp ituitary functions

Answer 1

Adenohypophysis

Secretion of releasing and inhibiting hormones

Question 2

Moa endocrine

Answer 2

Binds to plasma membrane

To intracellular receptors- cytoplasmic and nuclear

Question 3

Growth hormone moa

Answer 3

Stimulates liver to produce somatomedins
Produces growth at open epiphyses via IGF1
Children- linear growth of skel muscle
Adult- anabolic effect

Question 4

GH indications

Answer 4

Hypopituitary dwarfism

Non gh deficient short child

Question 5

Toxicity gh

Answer 5

CJD

Problems in hip, knee, spine

Question 6

Pegvisomant- gh antag

Answer 6

Acromegaly, excessive gh

Question 7

Somatomedin c

Answer 7

Igf-1

For growth failure due to igf1 deficiency

Question 8

Somatostatin

Answer 8

Blocks gh, tsh, insulin, glucagon

Question 9

Indications of somatostatin analogs

Answer 9

Acromegaly
Tsh secreting pituitary adenomas
Carcinoid tumors
VIP secreting tumors

Question 10

What is trh for

Answer 10

Diagnostics

Question 11

Thyrotropin alfa

Answer 11

Stimulate RAI by metastatic thyroid ca

Im, sq

Question 12

Corticotropin releaing hormone

Answer 12

Diagnostic!
Diff cushings from ectopic acth
Cushing inc acth

Question 13

Acth

Answer 13

Diagnostic

Tetracosactide

Question 14

Therapeutic goal of gnrh agonist

Answer 14

Reversible hypogonadism

Question 15

Indications gnrh agonist

Answer 15

Med menopause
Female disorders dept on estrogen(endometriosis)
Ivf therapy
Delay puberty in indiv with precocious puberty

Question 16

Side effects gnrh

Answer 16

Hot flushes

Osteoporosis

Question 17

Gnrh antag

Answer 17

Blocks receptors
No flare effect
Prevention of endogenous ovulation

Question 18

Abarelix

Answer 18

Palliative treatment of adv symptomatic prostate ca

Question 19

Cetrorelix and ganirelix

Answer 19

Inhibition of premature lh surges

Question 20

Fsh

Answer 20

Women- follicular devt, androgen to estrogen, twins

Men- spermatogenesis, production of abp

Question 21

Highly purified prep of human fsh from urine of post mens

Answer 21

Urofollitropin

Question 22

Follitropin alfa and beta

Answer 22

No lh activity

Question 23

Lh

Answer 23

Induce ovulation

Lutropin alfa- only source of pure lh

Question 24

Dopamine agonist

Answer 24

Prl secreting adenomas
Amenorrhea-galactorrhea
Acromegaly

Question 25

Cabergoline

Answer 25

Ergot
Agonist for d2 receptor
First line for prolactinomas

Question 26

Oxytocin

Answer 26

Iv, inactivated orally

Produce sustained uterine contraction

Question 27

Oxytocin effects can be inhibited by

Answer 27

Beta agonist- terbutaline, isoxsuprine
Mgso4
Inhalational anesthetic agents

Question 28

Oxytocin indications

Answer 28

Contraction stress test

Induction and augmentation of labor

Question 29

Oxytocin agonist

Answer 29

Carbetocin- control of postpartum bleeding

demoxytocin- prevention puerperal mastitis

Question 30

Vasopressin

Answer 30

Deficiency state- diabetes insipidus

Iv, im, intra nasal