Drugs For Reproductive System

Question 0

Diethylsilbestrol ae

Answer 0

Vaginal adenosis of offspring

Question 1

Estrogen in pregnancy

Answer 1

Inc fetal congenital defect

Inc hypercoagulability

Question 2

Major secretory product of the ovary

Answer 2

Estradiol

Question 3

Present in almost all OCP

Answer 3

Ethinyl estradiol- synthetic steroidal

Question 4

Used in palliative treatment of breast ca

Answer 4

Tamoxifen- estrogen antagonist

Question 5

Off label use as a fertility drug

Answer 5

Aromatase inhibitor

Question 6

Dec bone resorption, used in treatment for osteoporosis

Answer 6

Raloxifene- SERM

Question 7

Ae raloxifene

Answer 7

Thromboembolism

Question 8

Ovulating inducing agent

For patient with anovulatory cycle

Answer 8

Clomiphene

Question 9

Given to patients who has early menopause

Sensuality

Answer 9

Tibolone

Question 10

Drug treatment of hormone receptor positive metastatic breast ca

Answer 10

Fulvestrant

Question 11

Suppression of ovarian function

Inhibits midcycle surge of fsh and lh but does not suppress basal lh fsh

Answer 11

Danazol

Question 12

Danazol binds to what receptors?

Answer 12

Androgen
Progesterone
Glucocorticoids
Does not bind to intracellular estrogen

Question 13

Stimulates lipoprotein lipase activity favoring fat deposition

Answer 13

Progestin

Question 14

Progestins without androgenic activity

Answer 14

Desogestrel, gestodene, norgestimate

Question 15

Uses of progestin

Answer 15

In first trim to prevent habitual abortion
Return of ovulatory function and is more predictable
Long term ovarian suppression for the treatment of dysmenorrhea, endometriosis, hirsutism

Question 16

Principal hormone of corpus luteum

Relaxes smooth muscle of the uterus

Answer 16

Progesterone

Question 17

Inc lipid solubility
Dec first pass metab
Most closely resemble progesterone
17 alpha hydroxy derivatives

Answer 17

21 C compound

Question 18

17alpha ethinylandrogens

Answer 18

Structure as androgens but have progestationalactivity

Question 19

19 nor 13-ethyl steroids

Answer 19

Low androgenic activity
Produce decidual change
Effective gnrh inhibitors

Question 20

for luteal support in ivf protocols

Answer 20

Dyhydrogesterone

Question 21

Ae of progestins

Answer 21

Irregular menses
Breakthrough bleeding
Weight gain
Edema

Question 22

Mifepristone

Answer 22

Binds strongly to progesterone receptors, inhibiting activity of progesterone
In midluteal: luteolytic effect
Effective emergency post coital contraceptive

Question 23

Primary source of testosterone production in male

Answer 23

Leydig cells

Question 24

Primary testicular site of fsh action

Answer 24

Sertoli cells

Question 25

Sertoli cells produce

Answer 25

Estradiol
Mif
Inhibin
Activin

Question 26

Inhibin

Answer 26

Specific inhibitor of fsh secretion

Question 27

Clinical use of testosterone

Answer 27

Androgenic replacement therapy in hypogonadal men
Protein anabolic agent
May lead to short stature due to accelerated epiphyseal closure

Question 28

Androgen suppression

Answer 28

Prostatic ca
Treat severe male sexual disorders
Bph

Question 29

For prostatic carcinoma

Answer 29

Leuprolide acetate- gnrh agonist
Goserelin
Also bicalutamide- anti testosterone

Question 30

Cyproterone

Answer 30

With progestational activity
For hirsutism, acne in women
Dec sexual drive

Question 31

Finesteride

Answer 31

Inhibitors of 5a reductase enzyme
Prevent testosterone to dht
Blocks only 5a reductase type II
For bph male pattern baldness