Drugs For Reproductive System Flashcards
Diethylsilbestrol ae
Vaginal adenosis of offspring
Estrogen in pregnancy
Inc fetal congenital defect
Inc hypercoagulability
Major secretory product of the ovary
Estradiol
Present in almost all OCP
Ethinyl estradiol- synthetic steroidal
Used in palliative treatment of breast ca
Tamoxifen- estrogen antagonist
Off label use as a fertility drug
Aromatase inhibitor
Dec bone resorption, used in treatment for osteoporosis
Raloxifene- SERM
Ae raloxifene
Thromboembolism
Ovulating inducing agent
For patient with anovulatory cycle
Clomiphene
Given to patients who has early menopause
Sensuality
Tibolone
Drug treatment of hormone receptor positive metastatic breast ca
Fulvestrant
Suppression of ovarian function
Inhibits midcycle surge of fsh and lh but does not suppress basal lh fsh
Danazol
Danazol binds to what receptors?
Androgen
Progesterone
Glucocorticoids
Does not bind to intracellular estrogen
Stimulates lipoprotein lipase activity favoring fat deposition
Progestin
Progestins without androgenic activity
Desogestrel, gestodene, norgestimate
Uses of progestin
In first trim to prevent habitual abortion
Return of ovulatory function and is more predictable
Long term ovarian suppression for the treatment of dysmenorrhea, endometriosis, hirsutism
Principal hormone of corpus luteum
Relaxes smooth muscle of the uterus
Progesterone
Inc lipid solubility
Dec first pass metab
Most closely resemble progesterone
17 alpha hydroxy derivatives
21 C compound
17alpha ethinylandrogens
Structure as androgens but have progestationalactivity
19 nor 13-ethyl steroids
Low androgenic activity
Produce decidual change
Effective gnrh inhibitors
for luteal support in ivf protocols
Dyhydrogesterone
Ae of progestins
Irregular menses
Breakthrough bleeding
Weight gain
Edema
Mifepristone
Binds strongly to progesterone receptors, inhibiting activity of progesterone
In midluteal: luteolytic effect
Effective emergency post coital contraceptive
Primary source of testosterone production in male
Leydig cells
Primary testicular site of fsh action
Sertoli cells
Sertoli cells produce
Estradiol
Mif
Inhibin
Activin
Inhibin
Specific inhibitor of fsh secretion
Clinical use of testosterone
Androgenic replacement therapy in hypogonadal men
Protein anabolic agent
May lead to short stature due to accelerated epiphyseal closure
Androgen suppression
Prostatic ca
Treat severe male sexual disorders
Bph
For prostatic carcinoma
Leuprolide acetate- gnrh agonist
Goserelin
Also bicalutamide- anti testosterone
Cyproterone
With progestational activity
For hirsutism, acne in women
Dec sexual drive
Finesteride
Inhibitors of 5a reductase enzyme
Prevent testosterone to dht
Blocks only 5a reductase type II
For bph male pattern baldness
