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Pharmacology > Anti Gout And Anti Rheumatics > Flashcards

Anti Gout And Anti Rheumatics Flashcards

0
Q

Accelerating renal excretion of uric acid with uricosuric drugs

A

Probenecid, sulfinpyrazone

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1
Q

Reduce inflammation during Acute attacks

A

Nsaids, glucocorticoids

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2
Q

Reduce conversion of purines to uric acid

A

Allopurinol

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3
Q

Nsaids

A

Fewer git complaints except indometh
Indomethacin
Naproxen
Sulindac

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4
Q

Monoarticular cortico

A

Intraarticular

Triamcinolone

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5
Q

Polyarticular cortico

A

Intravenous-Methylprednisolone

Oral- prednisone

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6
Q

Colchicine

A

For Acute gout

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7
Q

Moa colchicine

A 
Dec lactic acid
Dec kinin formation
Dec inhib phagocytosis
Inhib migration
Block lipoxygenase pathway
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8
Q

Adverse effects of colchicine

Earliest signs of impending toxicity

A

Diarrhea, nausea, vomiting, abs pain

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9
Q

Warning colchicine

A

Pregnancy: category c

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10
Q

Moa probenecid

A

Dec tubular reabsorption of urate
Inc excretion of uric
Dec serum uric acid

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11
Q

Probenecid indication

A

Recurrent attacks

Start 2-3 weeks after

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12
Q

Adverse effects probenecid

A

Cns stimulation, convulsion, respi fail

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13
Q

Moa allopurinol

A

Inhib xanthine oxidase
Metab to oxypurinol- also inhib
Drob levels by day 2-3

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14
Q

Indication allopurinol

A

Chronic tophaceous gout

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15
Q

Ae allopurinol

A

Toxic epidermal necrolysi: SJS- first 2 mos treatment

16
Q

Drug interactions allopurinol

A 
Probenecid-inc half life
Mercaptopurine- inhib activation 
Cyclophosphamide- bone m. Suppression
Warfarin- interferes with inactivation
Ampicillin- rash
Theophylline- inc metab
17
Q

Prodrome Rheuma arthritis

A

Malaise
Fever
Weight loss
Morning stiffness

18
Q

Progression ra

A

Centripetal, symmetric

19
Q

Anti-ra

A

Antiinflamm

Dmards-slow acting

20
Q

Glucocorticoids

A

Used chronically for patients with uncontrollable ra

21
Q

Doc ra

A

Acetyl salicylic acid

Aspirin

22
Q

Slow acting anti- ra

A

Hydroxychloroquine sulphate

Azathioprine

23
Q

Moa hydroxychloroquine sulfate

A

Suppression of formation of antigen

24
Q

Interactions

A

Inc digoxin

Inc dermatitis with gold compounds

25
Q

Gold compounds

A

Does not cure
Moa: inhib phago, inhib lysosomal enzyme
Do not use with: penicillamine, anti malarial, hydro.., methotrexate, cyclophosphamide, azathioprine

26
Q

Methotrexate

A

Inhib dna precursor uptake

Pregnancy category x

27
Q

Penicillamine

A

Severe ra

Ae: oral ulcer, losso f taste, fever rash,

28
Q

Sulfasalazine

A

Neutropenia, thrombocytopenia

Pharmacology (15 decks)

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