Cholinergic Drugs

Question 0

Therapeutic purpose direct acting agonist

Answer 0

Initiate micturition (betanechol)
Miosis in treatment of glaucoma ( pilocarpine)

Question 1

Pilocarpine

Answer 1

Treatment of xerostomia (dry mouth) and glaucoma

Question 2

Therapeutic purpose of indirect acting agonist

Answer 2

Myasthenia gravis ( neostigmine, pyridostigmine)
Miosis (physostigmine, echothiophate
Counteract intoxication from anticholinergic drugs (physostigmine)

Question 3

Symptoms muscarinic toxicity

Answer 3

Miosis
Salivation
Sweating
Bronchoconstriction
Vomiting    Diarrhea

Question 4

CNS toxicity

Answer 4

Confusion
Ataxia
Slurred speech
Loss of reflexes

Question 5

NMJ toxicity

Answer 5

Depolarizing neuromuscular blockade
Weakness
Fatigue

Question 7

Metacholine

Answer 7

Bronchial hyperreactivity and asthmatic conditions

P: selectivity and inc toxicity

Question 8

Undesirable effects of choline esters

Answer 8

Flushing, belching, abdominal cramps, headache, salivation, sweating, difficulty of visual accomodation
BASHD SF

Question 9

Cholinergic effects

Answer 9

Diarrhea, urination, miosis, bradycardia, bronchoconstriction, emesis, lacrimation, sweating, salivation
DUMBBELSS

Question 10

Contraindications

Answer 10

Asthma, hyperthyroidism, acute peptic ulcer disease, coronary insufficiency

Question 11

Adverse effects of ache inhibitors

Answer 11

Topical: congested conjunctivae, myopic accomodation, transient lenticular opacity
Systemic: headache, syncope, brady, HPoN, bronchos

Question 12

Acetylcholinesterase activator

Answer 12

D: Pralidoxime, obidoxime, diactylmonoxime
U: organophosphate poisoning, at autonomic effector sites, negligible in cns
P: rapid injection can cause tachy, laryngeal spasm, muscle rigidity, transient neuromuscular blockage

Question 13

Atropine

Answer 13

Anti muscarinic
Prototype anti muscarinic drug
T: hallucinations, dry mouth, mydriasis, tachy,
Alice in wonderland

Question 14

Scopolamine

Answer 14

U: reduce tremors in parkinson’s, reduce vestibular disturbances, motion sickness
T: excitement, agitation, hallucination

Question 15

Neuromuscular blocking agents competitive

Answer 15

Blocks ach at nmj
U: during anesthesia
D: tubucurarine, atracurium, pancuronium
AE: respiratory paralysis, histamine release, bronchosp, HPoN, HPN

Question 16

Neuromuscular blocking agents non competitive

Answer 16

D:succinylcholine
AE: respiratory paralysis, fasciculation, bradycardia, inc glandular secretion, cardiac arrest,
U: skeletal muscle relaxation

Question 22

Betanechol

Answer 22

Stimulate smooth muscles, salivation
P: orally, subcutsneously, eye because IM and IV loses selectivity
U: paralytic and postoperative ileus