ANS Part 2

Question 0

Alpha 1 agonists given orally

Answer 0

Causes systemic vasoconstriction

Question 1

Most common side effect of terbutaline

Answer 1

Tachycardia, therefore they made inhalers

Question 2

D1

Answer 2

Ag: fenoldopam(antihypertensive)

Vasodilator and natriuretic

Question 3

D2

Answer 3

Bromocriptine- for hyperprolactinemia(acts as prolactin inhibiting)

Question 4

D4

Answer 4

Antag: clozapine- antipsychotic

Blocks dopamine receptors in cns

Question 5

Beta-phenylethylamine

Answer 5

Parent compound of sympatomimetic amines
Benzene ring + ethylamine side chains
CHANGING STRUCTURE CHANGES EFFICACY AND KINETICS
Terminal amino, benzene, alpha and beta carbon

Question 6

Pure alpha agonist phenylephrine

Answer 6

Inc arterial resistance, inc bp, dec hr

Mosent inotropic activity

Question 7

Pure beta agonist isoproterenol

Answer 7

Inc CO, inc SBP

Dec PVR, dec DBP

Question 8

Intraocular pressure

Answer 8

Alpha agonist- inc outflow of aqueous humor

Beta agonist- dec production of aqueous humor

Question 9

Epinephrine

Answer 9

Most potent stimulant
Non selective adrenergic agonist
Inc bp(ino, chrono--beta1, vasoconstriction-alpha1)
Inc glucose(metab)

Question 10

Epinephrine use and toxicity

Answer 10

Cardiac rhythm, hypersensitivity, relieve bronchospasm

Fear, anxiety, restlessness
Not indicated for those with arrythmia

Question 11

Norepinephrine

Answer 11

Non selective adre ag
Little effect on b2
Baroreceptor reflex overcomes chronotropic

Question 12

Dopamine

Answer 12

Non selec adre ag
Low- d1 vasod, inc renal bloodflow, in hypovolemic shock
D2 presynaptic inhibit ne release
Inter- b1
High- a1 vasoc

Question 13

Dopamine precaution, uses, toxicity

Answer 13

P: Those with mao inhibitor, hypovolemia
U: shock with low TPR, oliguria, cardiogenic and septicemic shock
T: nausea, vomiting, headache

Question 14

Isoproterenol

Answer 14

Potent b receptor agonist, little effect on a, same as ne
U: stimulate cardiac activity, asthma, shock(but replaced)
T: palpitations, tachycardia, headache, flushing, ischemia

Question 15

Resorcinol bronchod

Answer 15

Rsistant to degreadation by comt

D: metaproterenol, terbutaline, fenoterol

Question 16

Salbutamol

Answer 16

Inhalation and oral

D: isoetharine, salmeterol, formoterol, mga terol

Question 17

Ritodrine

Answer 17

B2 agonist, uterine relaxant

30% git, 90% drug excreted

Question 18

B2 agonist adverse effects

Answer 18

Excessive stimulation of b receptors
Skeletal muscle tremor
Tachycardia

Question 19

Phenoxybenzamine

Answer 19

Blocks a1 and a2
Dec PvR, inc CO
T: postural HPoN, reversible inhibition of ejaculation, miosis
U: vasospasm, acute hypertensive

Question 20

Ergot alkaloids

Answer 20

Partial agonist of a receptor, serotonin, dopamine
Ergotoxine: ergocornine+ergocristine+ergocryptine
U: contraction of postpartum uterus, migraine
T: vascular insufficiency, myocardial ischemia, gangrene
P: allergic potential