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Pharmacology > Autacoids > Flashcards

Autacoids Flashcards

0
Q

Rlease of other autocoids

A

PAF, metabolites of arachidonic acid, leukotriene D4, kinins

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1
Q

Histamine

A

From histidine via decarboxylation
L-histidine decarboxylase
Requires antigen and igE
Causes hypersensitivity and allergic response

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2
Q

H2

A

Gastric mucosa, cardiac muscle, mast cells, brain

Inc gastric acid secretion, inc pepsin, inc intrinsic factor

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3
Q

Triple response of lewis

A

Localized red spot- direct vasodilating effect
Flare- stim of axon reflexes
Wheal- inc capillary

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4
Q

Non sedating H1 blockers

A

Loratadine, fexofenadine

2nd generation

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5
Q

H1 blockers For motion sickness

A

Meclizine

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6
Q

Adverse effects 1st gen

A

Depression, sedation, fatigue, tinnitus, emesis, dry mouth,

Teratogenic: melanoma fibrosa, in breast milk, irritability, drowsiness

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7
Q

AE 2nd gen

A

Polymorphic ventricular tachycardia, prolonged QT interval

Leukopenia, agranulocytosis

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8
Q

H2 antag

A

U: gastric, ulcers, gerr
AE: confusion, dizziness
CIMETIDINE: inhibits microsomal enzymes, impotence, gynecomastia, galactorrhea

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9
Q

Serotonin

A

Rate limiting is tryptophan hydroxylase
Sibutramine- inhibits 5HT reuptake regulating food intake
Stimulates ACTH, GROWTH HORMONE, PROLACTIN
Inhibits: LH FSH TSH
Keymediator in migraine

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10
Q

Triptans

A

For migraines!
D: Sumatriptan, naratriptan, rizatriptan, zolmitriptan
AE: bitter taste, paresthesia, asthenia, fatigue, flushing
C/I: CV AND HPN!! ; naratriptan: with renal or hepatic impairment

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11
Q

Drugs that affect serotonin levels

A

Tryptophan
Inhibitors of membrane reuptake- imipramine, fluoxetine
Inhibitors of degradation- MAO
Inhibitors of neuron vesicle uptake- reserpine, tetrabenezine
Cyproheptadine- block h1 and serotonin
SSRI- antidepress

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12
Q

Ergot alkaloids

A

Egotamine
METHYSERGIDE- 5HT RECEPTOR ANTAGONIST
Bomocriptine
U: for HYPERPROLACTINEMIA: given bromocriptine

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13
Q

Enzymes acting upon arachidonic acid

A

5-LIPOXYGENASE

CYCLOOXYGENASE

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14
Q

PGD2

A

FLUSHING, NASAL STUFFINESS, DEC BP

F RING METABOLITES INC BP

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15
Q

Kidney and urine formation in lipid derived autacoids

A

EXAM
PGEs- inhibit water reabsorption by vasopressin
PGE2 and PGI2- inc renal blood flow, inc gfr, through vasod
TxA2- dec renal blood flow, dec gfr

16
Q

LOX metabolites

A

Stimulates release of aldosterone

17
Q

Properties of leukocytes

A

EXAM

Systemic administration- leukocytopenia

18
Q

In stomach, PAF

A

EXAM

most potent known ulcerogen

Pharmacology (15 decks)

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