Embryo: GI, Urinary, Pituitary Flashcards
What are the cranial and caudal limits of the GI tract?
Cranial limit = oropharyngeal membrane
Caudal limit = cloacal membrane
Vitteline Duct
Temporary connection during lateral folding
Endoderm is incorporated as midgut through vitteline duct.
Omphaloenteric Duct
Another name for vitteline duct
How is endoderm incorporated into GI tract?
epithelial lining and glands of the GI tract
How is mesoderm incorporated into GI tract?
Splanchnic (visceral) mesoderm: smooth muscle and connective tissue of GI tract
During folding mesoderm forms peritoneal around gut tube
Intraperitoneal vs. Retroperitoneal
Intraperitoneal = organs that are completely enclosed in mesentery and connected to wall via mesentery
Retroperitoneal = organ that lies against posterior body wall and is covered with peritoneum on anterior surface only
Peritoneum definition
serous membrane lining abdominal cavity and organs (we have parietal peritoneum and visceral peritoneum)
Parietal Peritoneum (definition and what is it derived form?)
Lines body wall
Derived from somatic mesoderm
Visceral Peritoneum (definition and what is it derived form?)
Lines organs
Derived from splanchnic mesoderm
Mesentery: definition
Mesentery = double layer folds of peritoneum that suspend organs from body wall and hold them to either ventral or dorsal wall
(We have a dorsal mesentery and a ventral mesentery)
Dorsal Mesentery (definition and what is it derived form?)
Holds midgut to posterior body wall. Runs entire length of gut tube.
Derived from splanchnic mesoderm
Ventral Mesentery (definition and what is it derived form?)
Associated with foregut.
Mesoderm of septum transversum that is between the liver and the foregut and the liver of the ventral abdominal wall.
Derived from splanchnic mesoderm
What can mesentery contain?
reminder: mesentery is a double-layer of peritoneum that suspends an organ from the body wall
can contain connective tissue, fat, blood vessels, lymphatics, nerves
Both dorsal mesentery and ventral mesentery are derived from ____.
Splanchnic mesoderm
Think: Mesentery means they are in contact with organs. Therefore from splanchnic.
Dorsal Mesentery Divisions
- Dorsal Mesogastrium (or greater omentum)
- Mesoduodenum
- Mesentery Proper
- Dorsal Mesocolon
Dorsal Mesogastrium
aka Greater Omentum
Dorsal mesentery division of the STOMACH
Greater Omentum
aka Dorsal Mesogastrium
Dorsal mesentery division of the STOMACH
Mesoduodenum
Dorsal mesentery division of DUODENUM
Mesentery Proper
Dorsal mesentery division of JEJUNA and ILEAL LOOPS
aka holds small intestine to posterior wall
Dorsal Mesocolon
Dorsal mesentery division of the COLON
Ventral Mesentery (definition and what is it derived form?)
Derived from septum transversum
Exists only in region of terminal esophagus, stomach and upper part of duodenum (ie FOREGUT)
Septum Transversum gives rise to _______
Mesodermal tissue that gives rise to central tendon of diaphragm and connective tissue in the liver
The liver grows into mesenchyme of septum transversum and divides _____ into ____&____
The liver grows into mesenchyme of septum transversum and divides the ventral mesentery into
LESSER OMENTUM and FALCIFORM LIGAMENT
Lesser Omentum (what is it and how is it formed?)
Extends from lower portion of esophagus, stomach and upper portion of duodenum to liver
formed from liver growing into mesenchyme of septum transversum and dividing ventral mesentery (into lesser omentum and falciform ligament)
Falciform Ligament (what is it and how is it formed?)
Extends from liver to ventral body wall
formed from liver growing into mesenchyme of septum transversum and dividing ventral mesenchyme (into lesser omentum and falciform ligament)
Round ligament of the liver
aka Ligamentum teres hepatis
free inferior margin of falciform ligament
contains obliterated umbilical vein
Ligamentum Teres Hepatis
aka Round ligament of the liver
free inferior margin of falciform ligament
contains obliterated umbilical vein
Hepatoduodenual Ligament
Free margin of lesser omentum connecting duodenum and liver
Contains the portal triad (bile duct, portal vein, hepatic artery)
Portal triad (what is it and where is it found?)
BILE DUCT, PORTAL VEIN, HEPATIC ARTERY
Contained within hepatoduodenual ligament (free margin of lesser omentum)
How is the ectoderm incorporated into GI tract? Think derivation
Enteric system (brain of the gut)
Enteric system is derived from neural crest cells (ectoderm)
What is the enteric system? Where is it derived from?
Ectodermal contribution to GI tract (derived from neural crest cells)
“Brain of the gut” - functions without innervation from the brain, it functions on it’s own.
Component of foregut
Pharynx Esophagus Stomach Proximal 1/2 duodenum (includes major duodenal papillae - pancreatic and bile duct papillae)
Components of midgut
Distal 1/2 duodenum Jejunum Ileum Secum Ascending Colon Proximal 2/3 Transverse Colon
Components of hindgut
Distal 1/3 Transverse Colon Descending Colon Sigmoid Colon Rectum Anus
Arterial Supply to GI tract?
Each gut region supplied by a major artery off of ABDOMINAL AORTA
- Foregut = CELIAC TRUNK ARTERY
- Midgut = SUPERIOR MESENTERIC ARTERY
- Hindgut = INFERIOR MESENTERIC ARTERY
Foregut derivatives
Pharynx, lower respiratory system, esophagus, stomach, proximal 1/2 duodenum (including pancreatic and bile duct papillae)
Associated organs: liver, gallbladder, pancreas, spleen (although spleen not digestive organ)
Esophagus & outgrowth
Immediately caudal to pharynx
Endodermal outgrowth week 4 = tracheobronchial diverticulum (aka respiratory diverticulum aka lung bud)
Tracheobronchial Diverticulum
(or respiratory diverticulum or lung bud)
Endodermal outgrowth from esophagus on ventral side of foregut
Becomes trachae, respiratory tree and lungs
Greater curvature / lesser curvature of stomach
Week 4
Stomach appears as fusiform dilation of foregut
As stomach enlarges, dorsal side expands faster = greater curvature of stomach
ventral side expands slower = lesser curvature
Stomach rotation: where do lesser/greater curvatures end?
90deg CLOCKWISE around longitudinal axis (anteroposterior axis) - as if looking SUPERIOR
ventral side (lesser curvature) = RIGHT
dorsal side (greater curvature) = LEFT
What are cardia and pylorus? Where do they go during stomach rotation?
Cardia = cephalic part of stomach Pylorus = caudal part of stomach
Both initially lie in midline. After growth and stomach rotation (alone anteroposterior axis):
- Cardia (cephalic) = slightly downward and left
- Pylorus (caudal) = up and to the right
What happens to dorsal mesogastrium during stomach rotation?
Carried to the left
This enlarges a space posterior to stomach (omental bursa aka lesser sac of peritoneum)
What is the omental bursa?
As a result of mesogastrium movement during rotation, space posterior to stomach is enlarged.
Space is called omental bursa or lesser sac of peritoneum.
Continuous with greater sac of peritoneum
What is the lesser sac of peritoneum?
As a result of mesogastrium movement during rotation, space posterior to stomach is enlarged.
Space is called omental bursa or lesser sac of peritoneum.
Continuous with greater sac of peritoneum
Spleen Premidorium
Mesodermal proliferation within dorsal mesogastrium
dorsal mesogastrium lengthens, portions between spleen and dorsal midline swing left, fusing with peritoneum of posterior abd. wall
INTRAPERITONEAL
Lienorenal ligament and gastrorenal ligament
Lienorenal ligament = connects spleen to body wall in left kidney region
Gastrolienal ligament - connects spleen to stomach
Greater Omentum definition
single, 4-layer sheet hangs from greater curvature of stomach
Greater Omentum formation
As stomach rotates, dorsal mesogastrium extends inferiorly, forms sac (space) lined by double-layers on either side.
Sac extends over transverse colon and small intestinal loops
Two sides of double layer of sac fuse, creating 1, 4-layered sheet off of greater curv. of stomach
In rotation, where does duodenum end?
Right side.
Think. Greater curv of stomach ends LEFT, where is pylorus? Duodenum comes from there.
Duodenum rotates because of rotation AND head of pancreas growth
What leads to duodenal swinging away fro midline? Where does it go?
Stomach rotation and head of pancreas growth.
Duodenum swings RIGHT (from midline)
Are the duodenum/pancrease retroperitoneal or intraperitoneal?
Duodenum and head of pancreas = RETROPERITONEAL (against dorsal body wall)
duodenal cap (near pylorus) = intraperitoneal
small portion of head of pancreas = intraperitoneal
Liver Primodrium (when and where?)
Week 3
appears at distal end of foregut as outgrowth of endodermal epithelium
= LIVER BUD (HEPATIC DIVERTICULUM)
What does the liver primodrium do?
As the liver bud (hepatic diverticulum) proliferates, it penetrates septum transversum which splits the ventral mesentery into falciform ligament and lesser omentum
What does the Common Bile Duct connect?
Narrow connection between the liver and foregut (DUODENUM)
Cystic Duct (what and where?)
Ventral outgrowth of common bile duct
connection between common bile duct and gallbladder
Dorsal pancreatic bud and ventral pancreatic bud
- what do they originate from?
- where do they grow from?
both originate from endodermal lining of duodenum
dorsal bud = grows from within the dorsal mesentery
ventral bud = outgrowth of the common bile duct
How do ventral and dorsal pancreatic buds come together? How are they arranged? What do they form?
As duodenum rotates, ventral pancreatic duct swings clockwise with it (because originates as outgrowth of common bile duct) until meets dorsal bud.
Ventral bud is behind and below dorsal bud.
Together = PANCREATIC DUCT
What do ventral pancreatic duct and dorsal pancreatic duct form respectively?
ventral pancreatic duct = ucinate process of the head, inferior portion of the head of pancreas
dorsal pancreatic duct = rest of head of pancreas, neck, body and tail
What are the midgut derivatives?
distal 1/2 duodenum (after pancreatic/bile papillae)
jejunum, ileum, cecum, appendix, ascending colon and proximal 2/3 transverse colon
What shape is the midgut?
U-shape around the superior mesenteric artery
Primary Intestinal Loop (what is it? how is it formed?)
Formed by rapid elongation of gut and mesenteries
Two parts: CEPHALIC LIMB & CAUDAL LIMB
formed around the superior mesenteric artery
Cephalic limb becomes…
Cephalic limb is a part of the primary intestinal loop
Becomes
- Distal 1/2 duodenum
- Jejunum
- Proximal Ileum
Caudal limb becomes…
Caudal limb is part of the primary intestinal loop
Becomes
- distal ileum, cecum, appendix, ascending colon, proximal 2/3 of transverse colon
What is between the two limbs of the primary intestinal loop?
The Vitteline Duct is between the caudal limb and the cephalic limb of the primary intestinal loop
Vitteline duct is a temporary connection bteween the gut tube and the yolk sac