Electron Transport Chain, Proton Force Flashcards

1
Q

What is the formula for electron flow?

A

ΔG°’ = -nFΔE°’

ΔG°’: Electron Transfer Energy

n: Number of Electrons

ΔE°’: Energy (Volts) added from both compounds

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2
Q

How many Pumps / Complexes in the ETC?

A

3 Pumps, 4 Complexes

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3
Q

What are the enzymes and the functions of Complex I?

A

NADH Q reductase or oxidoreductase

accepts 2e- from NADH and pumps 4H+

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4
Q

What are the enzymes and the functions of Complex II?

A

CoQ:

Ubiquinone

2e- carrier from Complex I to Complex III

Complex II:

succinate Q reductase

Accepts e- from FADH2 and gives them to Q for transfer to Complex III. We lose the 4H+ pumped in Complex I.

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5
Q

What are the enzymes and the functions of Complex III?

A

Cytochrome c reductase

pumps 4H+ from either NADH or FADH2

Cytochrome c

moves electrons (one at a time instead of 2 at a time as with Q) from Complex III to Complex IV

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6
Q

What are the enzymes and the functions of Complex IV?

A

Cytochrome oxidase

pumps 2H+, Needs 4e- to reduce oxygen to water at this terminal site of the ETC.

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7
Q

Where are NADH Q reductase and oxidoreductase in the ETC, and what is their function?

A

Complex I, accepts e- from NADH and pumps 4H+

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8
Q

Where is Ubiquinone in the ETC, and what is its function?

A

Complex II, 2e- carrier from Complex I to Complex III

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9
Q

Where is succinate Q reductase in the ETC, and what is its function?

A

Complex II, Accepts e- from FADH2 and gives them to Q for transfer to Complex III

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10
Q

Where is Cytochrome c reductase in the ETC, and what is its function?

A

Complex III, pumps 4H+ from either NADH or FADH2

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11
Q

Where is Cytochrome c in the ETC, and what is its function?

A

Complex III, moves electrons (one at a time instead of 2 at a time as with Q) from Complex III to Complex IV

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12
Q

Where is Cytochrome oxidase in the ETC, and what is its function?

A

Complex IV, pumps 2H+, Needs 4e- to reduce oxygen to water at this terminal site of the ETC.

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13
Q

How many electrons are pumped in the ETC per NADH?

A

10

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14
Q

How many electrons are pumped in the ETC per FADH2?

A

6

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15
Q

Glucose produces how many NADH?

A

6

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16
Q

Glucose produces how many FADH2?

A

2

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17
Q

Pyruvate produces how many NADH?

A

4

18
Q

Pyruvate produces how many FADH2?

A

1

19
Q

Acetyl CoA produces how many NADH?

A

3

20
Q

Acetyl CoA produces how many FADH2?

A

1

21
Q

When does NADH enter the ETC?

A

Complex I

22
Q

When does FADH2 Enter the ETC?

A

Complex II

23
Q

What is the Fo subunit of ATP Synthase?

A

A proton channel domain composed of a hydrophobic subunit that spans the mitochondrial membrane called half-channels

This is the C-Ring

24
Q

What is the F1 subunit of ATP Synthase?

A

The place where ATP is synthesized. Has 5 types of polypeptide chains.

25
Q

What is the blue ? indicating on ATP Synthase?

A

Rotor

Fo Domain

26
Q

What is the red ? indicating on ATP Synthase?

A

Catalytic Head

F1 Domain

27
Q

Where does the Synthesis of ATP occur in ATP Synthase?

A

Beta Subunits (F1)

28
Q

What happens in the O to L conformation?

A

Binds ADP and Pi

29
Q

What happens in the L to T conformation?

A

Forms ATP

30
Q

What happens in the T to O conformation?

A

Releases ATP and is open for binding more ADP and Pi

31
Q

Roughly, how many ATP are produced per NADH?

A

2.5

32
Q

Roughly, how many ATP are produced per FADH2?

A

1.5

33
Q

How many ATP are produced from one Glucose molecule?

A

30 in Muscle

32 in Liver

34
Q

How many ATP are produced from one Pyruvate molecule?

A

12.5

35
Q

How many ATP are produced from one Acetyl CoA molecule?

A

10

36
Q

How many protons are pumped per NADH?

A

10 Protons

37
Q

How many protons are pumped per FADH2?

A

6 Protons

38
Q

How many protons are pumped per Acetyl CoA?

A

Acetyl-CoA - 36 Protons

3 NADH + 1 FADH2

39
Q

How many protons are pumped per pyruvate?

A

46 Protons

1 NADH (P)

3 NADH (AcoA) + 1 FADH2 (ACoA)

40
Q

How many protons are pumped per glucose in muscle?

A

104 Protons

2 FADH2 (G) + 2 NADH (pyruvate) + 6 NADH (ACoA) + 2 FADH2 (ACoA)

41
Q

How many protons are pumped per glucose in the liver?

A

112 Protons

2 NADH (G) + 2 NADH (pyruvate) + 6 NADH (ACoA) + 2 FADH2 (ACoA)