Effects of training Flashcards

1
Q

Change VO2max with endurance training programme?

A

increase 15-20%

high initial = 2-3% increase - require high intensity exercise to improve
low initial = 50% increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Genetics determine training response

A

low responders = 2-3% increase VO2max
high = 50% with rigorous training

heritability of training adaptations is ~47%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Why does training imrpove VO2max?

A

VO2max = max CO x max a-VO2 diff

short duration improvements = increase SV
long duration = SV + a-VO2 increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How does endurance training increase SV

A

increase preload (EDV)
increase plasma volume
increase venous return
increase ventricular volume
increase contractility
decrease afterload (TPR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Max HR

A

lower after training due to:
vagal tone increased
greater filling time (EDV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Training-induced increases in arteriovenous O2 difference

A
  1. muscle blood flow increases
  2. improved ability of muscle fibres to extract and utilize O2 from blood
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Muscle blood flow increases

A

decrease SNS vasoconstriction
increase diameter and compliance of arteries
specific = permits greater volume flow per beat to limb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Improved ability of muscle fibre to extract and utilize O2 from blood

A

increase capillary density
increase mitochondrial number/volume
decrease diffusion distance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Time of adaptations

A

double within 5 weeks of training

improved oxidative capacity and ability to utilize fat as fuel
muscle mitochondria adapt quickly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Vascular remodeling on muscle blood flow

A

av differance greater = better O2 extraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Shift in muscle fibre type

A

fast to slow twitch type
reduction in fast
increase in slow

increase in slow myosin isoform = lower myosin ATPase activity but better efficiency with less ATP utilization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Increased number of capillaries surrounding muscle fibre

A

enhanced diffusion of oxygen
improved removal of wastes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Increase mitochondrial volume

A

greater capacity for oxidative phopshorylation
decreases cytosolic (ADP) due to increased ADP transporters (faster O2 uptake)
less lactate and H+ formation
less PC depletion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Increased mitochondrial turnover

A

breakdown of damaged mitochondria
replacement with healthy mitochondria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Endurance training fuel utilization

A

increased utilization of fat
sparing of glucose and muscle glycogen
decrease glucose metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Improve plasma FFA transport and oxidation into muscles

A

increased fatty acid binding protein and fatty acid translocase (FAT)

17
Q

Transport FFA from cytoplasm to mitochondria

A

higher levels carnitine transferase and FAT

18
Q

Mitochondrial oxidation of FFA

A

increased enzymes of B-oxidation
increased rate of acetyl-CoA formation

19
Q

Free radicals

A

contracting skeletal muscles produce
contain upaired electron
highly reactive
damage proteins, membranes, DNA
promote oxidative damage/muscle fatige (interfere with actin-myosin crossbridge formation)

20
Q

Primary changes in skeletal muscle as a result of endurance training

A

shift muscle fibre type
increase number capillaries
increase mitochondrial volume/turnover
increase fat metabolism
improve antioxidant capacity of muscles
improve acid-base balance

21
Q

Improve acid-base balance

A

increase mitochondrial number
less carb utilization = less pyruvate formed
increase NADH shuttles via ETC= less NADH available for acid formation
change LDH isoform

increase mitochondrial uptake of NADH and pyruvate = maintain blood pH

22
Q

Endurance + resistance training

A

promote protein synthesis

23
Q

4 primary signals

A

mechanical stretch
calcium
AMP/ATP
free radicals

24
Q

List 3 secondary signals

A

AMP kinase
PGC-1x
MTOR

25
Q

AMP kinase

A

AMPK
important signaling molecule activated during endurance exercise
promotes glucose uptake
linked to gene expression by activation of transcriptional activating factors

26
Q

PGC-1x

A

master regulator of mitochondrial biogenesis
promotes angiogenesis (increased capillarization)
synthesis of antioxidant enzymes
activated by AMPK and CaMK

27
Q

mTOR

A

key in resistance training adaptations
protein kinase-major regulator of protein synthesis and muscle size

28
Q

Causes of decrease in VO2max with detraining

A

decrease SV max due to rapid loss plasma volume

decrease VO2max due to decrease SV max
later decrease due to decrease a-v O2max

29
Q

Decrease max a-v O2 difference

A

decrease mitochondria
decrease oxidative capacity of muscle
decrease type 2a fibres
increase type 2x fibres

30
Q

Changes in muscle anaerobic exercise

A

improve muscle buffer capacity - increase H+ transporters/increase mitochondrial volume
hypertrophy type 2 fibres
elevates enzymes involved in ATP-PC system and glycolysis

31
Q

Capacity to transport glucose into skeletal muscle fibres

A

increased following several weeks of endurance exercise training
due to increase in number of GLUT4 glucose transporters