Effector T cell functions Flashcards
what are the two type of T cells in cell mediated immunity and what do they do?
- CD4 helper T cells produce cytokines that activate and recruit other cells
- CD8 cytotoxic T cells kill infected cells
T/F T cell clones express TCR that can recognize more than one peptide/MHC complex
False. TCR can only recognize one peptide/MHC complex
T/F recognition of antigen by T cell receptor is very specific
True
T/F presentation of antigen to T cells by APC is very specific
False. Is very diverse
T/F several peptides can be presented by different MHC I and MHC II molecules on the surface of the same DC
True
T cell patrol LN in search of what?
antigens with the perfect fit
what are the three CD4 helper T cell subsets
Th1, Th2, Th17
what does Th1 make and what does it activate
IFNy - activates macrophages
what does Th2 make and what does it activate
IL-4, IL-5, IL-13 - activates eosinophils
what does Th17 make and what does it activate
IL-17, IL-22 - activates neutrophils
what determines the fate of naive T cells?
different cytokines produced by DC or other innate cells that have recognized different types of microbes
how are macrophages activated by Th1 cells?
involves CD40L-CD40 and IFNy-IFNyR
what do macrophages do after being activated?
- produce cytokines
- upregulate MHC, costimulatory molecules, and microbicidal activities
what does IL-4 do
induces B cells to produce IgE
what does IL-5 do
induces eosinophil activation (mediates worm elimination)
