cytokines (only orange highlighted)

Question 1

IFNy involved with:

Answer 1

macrophage activation

Question 2

IFNalpha involved with:

Answer 2

NK activation

Question 3

IL-6, IL-1 & TNF involved with:

Answer 3

acute phase reactant release

Question 4

TNF & IL-1 involved with:

Answer 4

neutrophil recruitment

Question 5

IL-2 promotes

Answer 5

T cell proliferation

Question 6

IL-12 induces:

Answer 6

Th1 cell differentiation

Question 7

IL-4 induces:

Answer 7

Th2 cell differentiation and isotype switch to IgE

Question 8

IL-6 / TGFbeta induces:

Answer 8

Th17 cell differentiation

Question 9

Th1 cells produce:

Answer 9

IFNy

Question 10

Th2 cells produce:

Answer 10

IL-4, IL-5, and IL-13

Question 11

Th17 cells produce:

Answer 11

IL-17 and IL-22

Question 12

IFNy does what

Answer 12

• activates macrophages
• help B cells switch isotype of Ig to IgG

Question 13

IL-17 & IL-22 do what

Answer 13

lead to neutrophil activation

Question 14

IL-4 and IL-5 both do what

Answer 14

activate eosinophils

Question 15

what do T follicular helper cells produce in the germinal center

Answer 15

IL-21

Question 16

what does IL-21 do

Answer 16

helps B cells produce Ig’s

Question 17

which cells produce IFNalpha (5)

Answer 17

epithelial cells, fibroblasts, endothelial cells, macrophages, and DC

Question 18

which cells produce IFNy

Answer 18

lymphocytes and NK cells

Question 19

viral dsRNA binding to ________ triggers production of ______ that induces an ____________ in uninfected cells in the vicinity

Answer 19

TLR3, IFNa/B, antiviral state

Question 20

define antiviral state

Answer 20

if cells are infected with virus, its viral replication is inhibited

Question 21

what produces TNFa

Answer 21

activated macrophages

Question 22

what produces TNFB

Answer 22

activated T and B cells