Antigen Capture and Presentation Flashcards
where are antigens transported from and to
transported from tissue/mucosa to lymphoid organs
when antigens are transported to the lymphoid organs, what occurs
recognition by T cells
what resides in tissues and captures microbes and antigens
dendritic cells
how are cell-free antigens drained
via lymphatic vessels or enter blood stream
which type of DC are the majority
classical DC
where do classical DC (cDC) reside in the lymph node
T cell zone
what do immature DC do
capture and process antigen
how are DC activated
PRR
where do DC migrate to after they’re activated and how do they migrate
LN via chemokine gradient
what is upregulated during DC migration
chemokine receptors (CCR7) and costimulatory molecules
what do mature DC do
present protein antigens to T cells
what do T cells recognize on APCs
they recognize peptide antigens displayed by MHC molecules on the APC
where is the peptide located within the MHC
the pocket
what are the Human MHC proteins called
human leukocyte antigens (HLA)
T/F the genes are not polymophic
F. they are highly polymorphic
what are the two susceptibility factors for periodontitis
HLA-A9 and HLA-B15
T/F in both MHC I and MHC II the peptide binding cleft is located at the amino terminal
True
describe the chains of MHC I
one alpha chain, composed of a1, a2, and a3
what is variable and invariable in MHC I
a1 and a2 are variable, a3 is invariant
how many AA are in a MHC I
8-9 AA peptide
what is the a chain associated with in MHC I
beta2-microglobulin
describe the chains of MHC II
one alpha chain, composed of a1 and a2 and one beta chain composed of B1 and B2.
the groove accommodates how many AAs in MHC II
10-30 AA peptide
where is the variability in the MHC II
variability in a1 and B1, invariable in a2 and B2
