Easy analgesia Flashcards
Opioid action is mediated by which receptors
Gi/o G protein couple receptors
What does the NRM release?
5-HT
Enkephalins
What stimulates the NRM?
- PAG
- opioids
What does the LC release?
NA
Direct presynaptic inhibition
Stops ca+ influx
Direct postsynaptic inhibition?
Opens K+ channels
Indirect inhibition?
Works by activating inhibitory interneurones
m opioid receptors
Main analgesic action of opioids
but
respiratory depression sedation euphoria constipation dependence
d receptors
Some analgesic action
Pro-convulsant
k receptors
Spinal and peripheral level analgesia
but
dysphoria
sedation
HALLUCINATIONS
ORL1 receptors
Anti-opioid effect
Difference between COX1 and COX2
- COX 1 is constitutively active
- COX2 induced by inflammation
Most cells produce which prostaglandin in response to mechanical, thermal and chemical injury?
PGE2
What does PGE2 do?
Sensitises nociceptive neurones and causes hyperalgesia
PGE2 produced by COX-1 protects against acid environment which is why NSAIDS can cause gastric ulceration
Why are selective COX-2 inhibitors risky?
e.g. rofecoxib, celecoxib
they are prothrombotic
