E3 basal ganglia Flashcards

1
Q

direct pathway

A

disinhibits VA and PPN to promote initiation/synergies and inhibit posture

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2
Q

indirect pathway

A

inhibits VA and PPN to inhibit initation/synergies

facilitates posture

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3
Q

should draw overall path

A

d

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4
Q

parkinsons disorder

A
damage to dopaminergic SNc
underactive direct pathway
leading to over inhibited VA
overactive indirect pathway 
further inhibits VA
difficulty with initiation and other things
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5
Q

huntington chorea

A
damage to indirect part of striatum
underactive indirect path
leading to overactive VA
involuntary movements
later gaba cells degererate in direct path underactivity
initiation problems
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6
Q

hemiballismus

A

damage to subthalamic nucleus
decrease in GPi and SNr activity so overactivity of VA thalamus
contralateal

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