E1 Electron Transport Chain Flashcards
Where is the ETS located?
Inner mitochondrial membrane
What are the final products of aerobic metabolism?
CO2- Krebs
H20 and ATP- ETS
What part of the membrane is permeable to most small molecules and ions?
Outer membrane (mitochondrial porins)
What part of the membrane is impermeable to most ions and polar molecules? Why is this important?
Inner membrane (increase surface area) (Requires transporters/shuttles to get through the membrane (ATP, pyruvate, citrate)
What does the matrix contain?
Enzymes, reactants, coenzymes, DNA, ribosomes, metabolic intermediates
Is NADH an electron acceptor or donor?
Donor
How is NAD+ reduced?
Dehydrogenases
When NAD+ is reduced, this removed 2 hydrogen atoms. One H is removed with 2e- as a ________ ion and the other is removed as the _______ ions.
Hydride (H-); positive (H+)
What is important for oxidative phosphorylation in ETS?
The electron-transfer potential of electron carriers (NADH, FADH2)
Define negative standard reduction potential.
Reducing agent (NADH) wants to donate electrons (-deltaE)
Define positive standard reduction potential.
Oxidizing agent (O2) wants to accept electrons. (+deltaE)
What is another name for complex 1?
NADH dehydrogenase
Does complex 1/NADH dehydrogenase have a proton pump?
Yes
Where does complex 1/NADH dehydrogenase receive electrons from?
NADH
What happens when complex 1 accepts electrons from NADH?
NADH binds to NADH dehydrogenase then to FMN and become FMNH2. FMNH2 donates 2 electrons to coenzyme Q/ubiquinone via iron/sulfur centers. FMN is recycled.