Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Infectious Disease > Drugs Three Last Time > Flashcards

Drugs Three Last Time Flashcards

RIP Etika

1
Q

Amphotericine B mechanism of action

A

Bind ergosterol and disrupt fungal cell membrane by making it leak intracellular content especially K+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Example of polyene antibiotic

A

Amphotericin B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Amphotericin B spectrum

A

Broad for fungi such as histoplasma, cryptococcus, candida, DOC for most systemic mycoses in life threatening fungal infections especially

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Amphotericin B ADRs

A

Renal toxicity, infusion related thrombophlebitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Amphotericin B resistance

A

Very rare, only after long term exposure fungi reduce ergosterol content in cell membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Amphotericin B drug interactions

A

Use with other nephrotoxic drugs increases risk of injury to the kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Flucytosine is almost always used in combo with…

A

…amphotericin B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Flucytosine spectrum

A

Narrow, candida and cryptococcus species

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Flucytosine mechanism of action

A

Taken up by cell and converted via cytosine deaminase to 5-fluorouracil that then disrupts DNA and RNA synthesis (only in organisms that have cytosine deaminase, humans and many fungi do not)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Flucytosine absorption

A

GI route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Flucytosine ADRs

A
  • Hematologic bone marrow depression

- Hepatotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Example of pyrimadine analog

A

Flucytosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Examples of azoles

A
  • Fluconazole
  • Itraconazole
  • Ketoconazole
  • Posaconazole
  • Voriconazole
  • Isavuconazole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Azoles mech of aciton

A

Inhibit synthesis of ergosterol disrupting fungal cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Azoles ADR

A

Inhibit hepatic p450 enzymes increasing plasma levels of many drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Ketoconazole spectrum

A

Many fungi causing systemic, and some causing superficial infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Ketoconazole absorption

A

PO

18
Q

Fluconazole spectrum

A

Primarily candidiasis and cryptococcus

19
Q

Fluconazole absorption

A

PO

20
Q

Fluconazole is generally less toxic but has the same effectiveness as….

A

ketoconazole

21
Q

Itraconazole spectrum

A

Broad, Blastomycosis, histoplasmosis, onychomycosis, aspergillosis

22
Q

Cisapride interacts with what to increase risk of torsades de pointes

A

Intraconazole

23
Q

Itraconazole ADR

A

Neg inatropic effect

24
Q

Miconazole

A

Topical treatment because of toxicity rarely given for systemic infections (must be IV)

25
Q

Voriconazole spectrum

A

Broad spectrum

  • blastomycosis
  • histoplasmosis
  • onchyomycosis
  • aspergillosis
26
Q

Posaconazole spectrum

A

Asprgillus and candida including resistant infections

27
Q

Posaconazole absorption

A

PO

28
Q

Isavuconazole spectrum

A

Aspergillus and mucormycosis

29
Q

Isavuconazole ADR

A

Steven Johnson syndrome

30
Q

Echinocandins mechanism of action

A

Disruption of fungal cell wall

31
Q

Echinocandins spectrum

A

Narrow, aspergillus and candida species

32
Q

Echinocandins absorption

A

IV only

33
Q

Echinocandin examples

A
  • anidulafungin
  • caspofungin
  • microfungin
34
Q

Caspofungin spectrum

A

Invasive aspergillosis in patients intolerant to other treatments and systemic candida

35
Q

Caspofungin is generally better tolerated than…

A

…amphoB

36
Q

Tinea pedis/cruris/corporis/capitis treatment

A

Topical treatment such an azole

37
Q

Vulvovaginal candidiasis treatment

A

PO fluoconazole

38
Q

Oral candidiasis treatment

A

Topical agents such as miconazole, or in immunocompromised patient fluconazole or ketoconazole

39
Q

Clotrimazole

A

DOC for dermatophytic infections and candiasis of skin, mouth and vagina, can cause stinging when applied

40
Q

Griseovulvin

A

PO treatment for superficial mycoses by implanting into the keratin of the cells

Infectious Disease (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions