Drugs Of Abuse Flashcards

1
Q

What is abstinence syndrome?

A

The signs and sx that occur on withdrawal of a drug in a dependent person

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2
Q

What is addiction?

A

Compulsive drug using behavior in which the person uses the drug for personal satisfaction often in the face of known risks to health

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3
Q

What is a controlled substance?

A

A drug deemed to have abuse liability that is listed on governmental schedules of controlled substances; such schedules categorize illicit drugs, control prescribing practices, and mandate penalties for illegal possession, manufacture and sale of listed drugs

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4
Q

What is dependence?

A

A state characterized by signs and sx frequently in the opposie of those caused by a drug, when it is withdrawn from chronic use or when the dose is abruptly lowered

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5
Q

What is a designer drug?

A

A synthetic derivative of a drug, with slightly modified structure but no major change in pharmacodynamic action; circumvention of the schedules of controlled drugs in a motivation for the illicit synthesis of designer drugs

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6
Q

What is tolerance?

A

A decreased response to a drug necessitating larger doses to achieve the same effect; can result from increased disposition of the drug (metabolic tolerance), an ability to compensate for the effects of a drug (behavioral tolerance) or changes in receptor or effector systems involved in drug actions (functional tolerance)

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7
Q

What is sensitization?

A

An increase in response with repetition of the same dose of the drug (dose response curve shifts to the left)

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8
Q

What is withdrawal?

A

Adaptive changes that become fully apparent once drug exposure is terminated; generally due to readapation of the CNS to the absence of the drug of dependence; withdrawal is the evidence of physical dependence

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9
Q

What is the criteria for schedule I drugs?

A

No medical use; high addiction potential

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10
Q

What is the criteria for schedule II drugs?

A

Medical use; high addiction potential

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11
Q

What is the criteria for schedule III drugs?

A

Medical use; moderate abuse potential

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12
Q

What is the criteria for schedule IV drugs?

A

Medical use; low abuse potential

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13
Q

Which painkillers are commonly abused?

A

Codeine, fentanyl, morphine, hydrocodone, oxycodone

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14
Q

Which anti-depressants are commonly abused?

A

Diazepam, alprazolam, citalopram, zolpidem and zaleplon

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15
Q

Which stimulants are commonly abused?

A

Adderal, dexedrine, methylphenidate, desoxyn, destrostat

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16
Q

Which drugs are used to treat dependence and addiction?

A

Opioid receptor antagonist (naloxone, naltrexone), synthetic opioid (methadone), partial mu opioid receptor agonist (buprenorphine), nicotinic receptor partial agonist (varenicline/chantix), benzos (oxazepam, lorazepam), receptor antagonist (acamprosate)

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17
Q

Which drugs are used in the treatment of acute alcohol withdrawal syndrome?

A

Diazepam (valium), lorazepam (ativan), oxazepam, thiamine (B1)

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18
Q

Which drugs are used for the prevention of alcohol abuse?

A

Acamprosate (reduces the desire to drink alcohol), disulfiram (antabuse), naltrexone

19
Q

Which drugs are used for the tx of acute methanol or ethylene glycol poisoning?

A

Ethanol and fomepizole

20
Q

What can dronabinol be used for?

A

N/V, for marijaunna abuse

21
Q

What are the overdose effects of barbituates, benzos and ethanol?

A

Slurred speech, drunken behavior, dilated pupils, weak and rapid pulse, clammy skin, shallow respiration, coma and death

22
Q

What are the withdrawal sx of barbiturates, benzos and ethanol?

A

Anxiety, insomnia, delirium, tremors, seizures and death

23
Q

What are the overdose effects of heroin and other strong opioids?

A

Constricted pupils, clammy skin, nausea, drowsiness, respiratory depression, coma, death

24
Q

What are the withdrawal sx of heroin and other strong opioids?

A

Nausea, chills, cramps, lacrimation, rhinorrhea, yawning, hyperpnea, tremor

25
Q

What are examples of drugs that are abused but not necessarily addictive?

A

LSD, mescaline, psilocybin, PCP (phencyclidine), ketamine

26
Q

What are the long term effects of PCP?

A

May lead to irreversible schizophrenia like psychosis

27
Q

What are the long term effects of LSD?

A

Can cause flashbacks of altered perception years after consumption

28
Q

How much pure alcohol does a standard drink contain?

A

0.6 ounces (14g or 1.2 tablespoons)

29
Q

How much is a standard drink of beer?

A

12 ounce beer (5% alcohol content)

30
Q

How much is a standard drink of malt liquor?

A

8 oz (7% alcohol content)

31
Q

How much is a standard drink of wine?

A

5 oz (12% alcohol content)

32
Q

How much is a standard drink of distlilled spirits (gin, rum, vodka, whiskey)?

A

1.5 oz of 80-proof (40% alcohol content)

33
Q

How long does 1 oz of alcohol take to metabolize?

A

1 hour (ex. Six 1 oz whiskey shots takes 6 hour to metabolize)

34
Q

What is binge drinking for women?

A

4 or more drinks during a single occassion

35
Q

What is binge drinking for men?

A

5 or more drinks during a single occassion

36
Q

What is considered heavy drinking for women?

A

8 or more drinks per week

37
Q

What is considered heavy drinking for men?

A

15 or more drinks per week

38
Q

What is the clinical effect of a BAC of 50-100?

A

Sedation, subjective “high”, slower reaction times

39
Q

What is the clinical effect of a BAC of 100-200?

A

Impaired motor function, slurred speech, ataxia

40
Q

What is the clinical effect of a BAC of 200-300?

A

Emesis, stupor

41
Q

What is the clinical effect of a BAC of 300-400?

A

Coma

42
Q

What is the clinical effect of a BAC of >500?

A

Respiratory depression and death

43
Q

What BAC is sufficient for the convinction of driving while under the influence?

A

BAC above 80-100 for adults or 10mg for persons under 21