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NMSP Exam 3 > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

What is an additional indiciation for bupropion?

A

Nicotine withdrawal

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2
Q

What is an additional indiciation for imipramine?

A

Enuresis

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3
Q

What is an additional indiciation for duloxetine?

A

Diabetic peripheral neuropahty, fibromyalgia, chronic MSK pain and stress incontinence

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4
Q

What are the 3 major hypotheses for depression?

A

Neurotrophic, monoamine and steroids hypothesis

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5
Q

What is the neurotrophic hypothesis?

A

Brain-derived neurotrophic factor (BDNF) is thought to be neuroprotective and decreased in depressed pts

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6
Q

What is the monoamine hypothesis?

A

NE, serotonin, dopamine, and glutamate all play a role in depression

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7
Q

What is the steroids hypothesis?

A

Glucocorticoids, thyroid hormones and sex homrones play a role

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8
Q

What are the 5 R’s?

A

Response, remission, recovery, relapse and recurrence

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9
Q

What is response?

A

> 50% reduction in sx from baseline; not well just better; partial response = >25% reduction but <50% reduction in sx from baseline (less than full response)

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10
Q

What is remission?

A

Symptom free (very low to no sx); not only better, but well; a healthy state of functioning

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11
Q

What is recovery?

A

6-12 months of ongoing remission; not cured

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12
Q

What is relapse?

A

Return of sx after remission but before recovery

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13
Q

What is recurrence?

A

Reutrn of sx after recovery

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14
Q

What is Milnacipran?

A

An SNRI used only for fibromyalgia

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15
Q

What is Fluvoxamine?

A

An SSRI only for OCD

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16
Q

What is withdrawal syndrome?

A

All antidepressants are known to or can be asociated with this; occurs when pt abruptly discontinues meds so slow titration downward is recommended (deprescribing)

17
Q

What are the sx of withdrawal syndrome?

A

Flu like sx, insomnia, nausea, imbalance (lightheadedness), sensory disturbances (electric shock like/paresthesia) and hyperarousal (lower risk with long acting agents yet even possible with XR type); FINISH

18
Q

What is the black box warning for all antidepressants?

A

Increase risk of suicidal ideations, behaviors and actions; highest risk in children/adolescents and YA (<24yo)

NMSP Exam 3 (11 decks)

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