Drugs Flashcards
Penicillin resistance comes from bacteria that contains?
Beta-lactamase
MOA of amoxicillin
Disrupts cell wall & inhibits cross linking between peptidoglycan chain
Why doesn’t amphotericin B work aginst bacteria?
Ergosterol (fungus cell wall )
Polyene antifungal are specific to fungus because?
It attack the sterol that are present in fungi but not bacteria
What binds to 30s ribosome & inhibits mRNA trnslation?
AMG
What don’t you treat patients with penicillin & erythromycin?
Penicillin only works on growing cells
MOA of fluorouracil?
Suicide inhibitor of thymidylate synthase
interefers with DNA synthesis by blocing thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid
What is a reversible nonselective COX inhibitor that is more potent than aspiring
Naproxen
What medication blocks prostaglandins?
Aspirin
What’s the lab test for wafarin?
Prothrombin test (increases) (Hemophilia has increased PPT)
Sulfonamides compete with which molecule in their MOA?
PABA to inhibit folic acid synthese –> can’t make purines/ pyrmidines
What does sulfonamides block on top of dihydrofolate?
Purines & pyrmidine synthess
How does detergent kill bacteira by interfering with function of cell membranes?
Destroy fatty cell parts
MOA of which drug is inhibition of Na/K ATPase that causes increase in intracellular Na levels?
Digoxin
What medication is a DNA gyrase inhibitor?
Ciprofloxacin (end with oxacins)
What’s the MOA of clindamycin?
50s ribosomes
How does rifampin work?
RNA synthesis inhibitor
TX of TB; stops mRNA transcription
What’s the most common bacteria vaccine given in US?
DTP
Bordetella pertusis vaccine is what type of vaccine?
Killed
Live attenuated vaccine is an ?
Active immunity
Sabin: oral/alive; SalK: killed
What’s the antibiotic used for meningitis caused by Haemophilus influenza?
Ceftriaxone
MOA of Viagra?
inhbit CGMP specific PDE5 which regulates blood flow into penis
All will depress respiration excpet?
Cocaine
