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;) > Collagen & Bones > Flashcards

Collagen & Bones Flashcards

1
Q

How is vitamin C formed?

A

Hydroxylation of proline & lysine during collagen synthesis

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2
Q

What happens during collagen synthesis?

A

Lysyl oxidase cross links collagen

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3
Q

What does lysyl oxidase need as a cofactor?

A

Copper

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4
Q

What is the 3 AA sequence in collagen?

A

Glycine- (proline) - (lysine)

Lysine –> crosslinking

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5
Q

What is present in collagen but is not elastin?

A

hydroxylysine

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6
Q

What is only found in collagen & reticular fibers?

A

Tropocollagen

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7
Q

What does elastin have?

A

Glycine, alanine, proline, hydroxlyproline and tropoelastin

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8
Q

What is not needed for synthesis of collagen?

A

Vitamin K & Folic acid

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9
Q

What is responsible for calcium regulation?

A

PARAthyroid hormone (increases serum calcium)

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10
Q

What’s the main role of calcitonin?

A

bone resoprtion

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11
Q

Osteoclasts become?

A

Monocytes

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12
Q

What is not in periosteum?

A

Osteocytes

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13
Q

What cytokines are found in osteolcastic bone?

A

IL-1, IL6, PGE2, TNF-alpha, MMPS

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14
Q

What are housed in Howships’s Lacunae?

A

Osteoclasts

resoprtion

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15
Q

What is first resrobed by osteoclasts?

A

Trabecular bones –> lacuna (deposit compact bone in ti later)

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16
Q

what is a thin layer of c.t that lines the surface of bony tissues that form the medullary cavity of long bones?

A

Endosteum

17
Q

What type of bone do you see after 2-3 years at the site of injury

A

Compact bone

18
Q

What is not found in the compact bone?

A

Fibroblasts

19
Q

What’s the formula of most common salt in the bone?

A

HA Ca10(PO4)6(OH)2

20
Q

What is Vitamin D called in
Children?
Adults?

A

Children: rickets
adults: osteomalacia

21
Q

Vitamin D

Where does 25 hydroxycholecalciferol gets converted to 1,25 dihydroxycalciferol?

A

Kidney

22
Q

where do you get vitamin D from?

A

Skin, liver, kidney

;) (24 decks)

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