Drug Toxicities

Question 1

5 to know

Answer 1

-lithium
-lanoxin/digoxin
-aminophylline
-dilantin (phenytoin)
-bilirubin

Question 2

Lithium

Answer 2

Anti-mania drug used for Bipolar
Therapeutic: 0.6 - 1.2
Toxic: over 2

Question 3

Lanoxin/Digoxin

Answer 3

Treats A-fib & CHF
Therapeutic: 1 -2
Toxic: over 2

Question 4

Aminophylline

Answer 4

Muscle spasm relaxer for the airway
Therapeutic: 10 -20
Non- therapeutic: less than 10 (increase dose & assess compliance)
Toxic: over 20

Question 5

Dilantin (phenytoin)

Answer 5

Seizure med
Therapeutic: 10 - 20
Toxic: over 20

Question 6

Bilirubin

Answer 6

NOT A DRUG - product of breakdown of the mother’s RBC in NEWBORNS
elevated: 10 -20
Toxic: over 20 (hospitalize at 14-15)
leads to jaundice

Question 7

Toxicity Patterns

Answer 7

-1s & 10s (therapeutic)
-2s & 20s (toxic)
2s: LOW # -> Lithium & Lanoxin
20s: HIGH # -> aminophylline, dilantin, bilirubin

Question 8

Jaundice

Answer 8

yellow skin from excess bilirubin in blood
-pathologic (born w/) = problem
-Physiologic (develops) = fine

Question 9

Kernicterus

Answer 9

excess bilirubin in brain
- level in blood is over 20
-causes aseptic (sterile) meningitis or encephalopathy
-DEADLY
-can lead to Opisthotonos
position newborn assumes; hyperextended posture, MEDICAL EMERGENCY