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Year 2 ALS > Drug list block 9 > Flashcards

Drug list block 9 Flashcards

1
Q

Colistin

A

Polymyxin antibiotic- disrupts bacterial cell wall and change permeability.
Targets gram negative bacteria

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2
Q

Aciclovir

A

Inhibits viral DNA polymerase

anti viral against Herpes simplex virus inc. shingles

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3
Q

Amanatadine

A

Inhibits viral ion channel M2 so virus can’t uncut

Anti viral and Parkinson’s drug when paired with L-dopa

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4
Q

Amprenavir

A

Inhibits HIV-1 protease to stop protein cleavage

HIV drug

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5
Q

Zidovudine

A

Nucleoside reverse transcriptase inhibitor

HIV drug

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6
Q

Clotrimazole

A

Inhibits demethylase to stop conversion of lanosterol to ergosterol for fungal cell walls
Anti-fungal

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7
Q

Nystatin

A

Binds to ergosterol in fungal cell membranes and makes holes

Anti-Fungal

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8
Q

Pyrimethamine

A

Folate antagonist

Anti-parasitic- malaria, toxoplasmosis

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9
Q

Quinine

A

In habits haem polymerase in parasite

Anti-parastitic- Malaria

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10
Q

Artemether

A

Interacts with haem in parasite- peroxide.
Anti-malarial.
Given with lumefantrine as that has a longer half life

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11
Q

Griseofulvin

A

Inhibits fungal mitosis

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12
Q

Clobetasone

A

Upregulates lipocortins and inhibits thromboxane and cox enzymes.
Glucocorticoid- high potency topical cream

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13
Q

Dacarbazine

A

Alkylating agent chemotherapy for lymphoma and leukaemia

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14
Q

Cyclophosphamide

A

Alkylating agent chemotherapy for lymphoma and leukaemia

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15
Q

Rituximab

A

Monoclonal antibody causes B cell lysis by being an antibody against CD20 antigen on normal and malignant B cells
Used for rheumatoid arthritis with methotrexate
For non-hodgkins lymphoma and CLL

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16
Q

Doxorubicin

A

Anthracycline chemotherapy than inhibits topoisomerase II

Used for most solid tumours

17
Q

Paclitaxel

A

Taxoid chemotherapy- bind to beta subunit of microtubules to hyper stabilise them so can’t reorganise and under cell division.
For ovarian and breast cancer

18
Q

Tamoxifen

A

SERM
Decreases oestrogen response
Used in breast cancer

19
Q

5-Flurouracil

A

Antimetabolite- pyrimidine analogue chemotherapy.
S phase specific
Breast, colon, stomach and head and neck cancer

20
Q

Etoposide

A

DNA topoisomerase inhibitor chemotherapyUsed for lung and testicular cancer

21
Q

Vinblastine

A

Tubulin polymerase inhibitor chemotherapy.

Inhibits mitosis at metaphase.Used for bladder, breast, kidney and testicular cancer

22
Q

Tretinoin

A

Binds to RAR’s linked in APL to reduce proliferation.
A vitamin A analogue
Used for acne and acute promyelolitic leukaemia

Year 2 ALS (14 decks)

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