Antibiotics

Question 1

Penicillins

Answer 1

Beta lactams, interfere with PBP and inhibit enzyme to prevent bacterial cell wall formation.
Bacteriacidal
Amoxicillin

Question 2

Cephalosporins

Answer 2

Beta lactams- interfere with PBP and inhibit enzyme to prevent bacterial cell wall formation.
Bacteriacidal
Cefradine

Question 3

Glycopeptides

Answer 3

Bind to cell wall subunit to another can’t bind and cross link.
Gram positive bacteria only
Vancomycin

Question 4

30S inhibitors

Answer 4

Aminoglycosides- Gentamicin- bactericidal

Tetracyclines- Oxytetracycline, doxyclycline- bacteriostatic

Question 5

50S inhibitors

Answer 5

Macrolides- Erythromycin

Question 6

tRNA inhibitors

Answer 6

Puromycin

Mupiocin

Question 7

Block EF-G elongation factor

Answer 7

Fusidic acid- creams

Question 8

Quinolones

Answer 8

Inhibits DNA replication by blocking Topoisomerase II
Ciprofloxacin
Broad spectrum

Question 9

Rifamycins

Answer 9

Blocks mRNA synthesis- inhibits RNA polymerase

Rifampicin- TB

Question 10

Sulphonamides

Answer 10

Inhibit PABA to prevent formation of dihydrofolic acid
Bacteriostatic
Sulfamethazole
Broad spectrum

Question 11

Trimethoprim

Answer 11

Structural analogue of folic acid- inhibits DNA synthesis.

Bacteriostatic