Cancer drugs

Question 1

Taxanes

Answer 1

Inhibits microtubule function by hyper stabilising them

Paclitaxel- ovarian and best cancer

Question 2

Anthracycline

Answer 2

Inhibits Topoisomerase II
Doxorubicin
Treats solid tumours

Question 3

5- Flurouracil

Answer 3

Inhibits DTMP synthesis

Question 4

Methotrexate

Answer 4

Inhibits purine synthesis

Question 5

Pentostatin

Answer 5

Inhibits adenosine deaminase

Question 6

Monoclonal antibodies to block extracellular domain of EGFR

Answer 6

Cetuximab

Panitumumab

Question 7

Small molecule kinase inhibitors

Answer 7

Inhibits EGFR tyrosine kinase
Gefintinib
Erlotinib

Question 8

Imatinib

Answer 8

Blocks affect of BCR-ABL translation Philadelphia chromosome. Treats CML

Question 9

Vemurafenib

Answer 9

Inhibits BRAF-V600

Treats Melanoma

Question 10

Trastuzumab

Answer 10

Block HER2

Treats HER2 positive breast and gastric cancer

Question 11

Cetuximab

Answer 11

Blocks RAS

Treats colorectal cancer

Question 12

PD-1 inhibitors

Answer 12

Pembrolizumab
Nivolumab
Treats metastatic melanoma
Prevent PD-1 and PD-LI interaction to prevent tumour from hiding from immune system

Question 13

PD-LI inhibitors

Answer 13

Atexolizumab

Same action as PD-1 Inhibitors

Question 14

CTLA 4 inhibitors

Answer 14

Block CTLA 4 to stop tumours from hiding from immune system.
Monoclonal antibody- Ipilimumab
Used for melanoma, Bladder cancer, Non small cell and small cell lung cancer

Question 15

How does Bevacizumab work?

Answer 15

Inhibits VEGF to stop angiogenesis in tumours

Question 16

Ovaparib

Answer 16

PARP inhibitor to trigger apoptosis of cancer cells

Used in ovarian cancer