Drug-Induced Kidney Disease- Intrinsic Renal; AIN Flashcards
1
Q
AIN is what type of reaction?
A
Type IV hypersensitivity reaction
2
Q
Patho of AIN
A
Immune activation/hypersensitivity –> leukocyte infiltration –> inflammation –> AIN
3
Q
Clinical triad of AIN
A
Fever, rash, eosinophilia
4
Q
Drugs that can cause AIN
A
Beta-lactams, NSAIDs, sulfa-containing drugs, PPIs
5
Q
Nonpharm treatment of AIN
A
Stop offending drug
Avoid cross-reacting drugs
Supportive care
6
Q
Steroid treatment and AIN
A
Early, aggressive steroid therapy may improve long-term renal outcomes; complete kidney function recovery is possible in the first 2 weeks of treatment
