DILD- Risk Factors, Naranjo Scale

Question 1

Lung mechanisms of injury

Answer 1

Oxidant injury
immune-complex mediated
interference with matrix formation
interference with lipid metabolism

Question 2

Purpose of the Naranjo Scale

Answer 2

Estimates the probability of an adverse event

Question 3

Score on the Naranjo Scale that means the event is an ADR

Answer 3

5 (or higher)

Question 4

Significance of the question “Did the adverse event appear after the suspected drug was administered?”

Answer 4

The drug was given in the same timeframe when it would cause the ADE

Question 5

Significance of the question “Was the reaction more severe when the dose was increased or less severe when the dose was decreased?”

Answer 5

Determines if the reaction is dose-related

Question 6

Patient risk factors for DILD

Answer 6

Extremes of age
RA or pre-existing lung disease
Impaired renal/hepatic disease
Genetics

Question 7

Drug-related risk factors for DILD

Answer 7

Dose of administration rate, treatment duration, oxygen therapy, radiation therapy, cumulative doses

Basically, anything that will decrease antioxidants

Question 8

General approach to treating DILDs

Answer 8

Stopping the med is usually the most important step, but steroids could be helpful in some situations