CF- Elexacaftor/Tezacaftor/Ivacaftor DI

Question 1

Elexacaftor/tezacaftor/ivacaftor brand name

Answer 1

Trikafta

Question 2

Elexacaftor and tezacaftor MoA

Answer 2

Same as before lol, fix the defective CFTR protein so it can move to the proper place on the airway cell surface

Question 3

Is elexacaftor a CFTR potentiator or corrector?

Answer 3

Corrector

Question 4

Ivacaftor MoA in Trikafta

Answer 4

Same as before, facilitates opening of the chloride channel (acts as the CFTR potentiator)

Question 5

What CF mutation class does Trikafta work on?

Answer 5

Class II

Question 6

Trikafta indication

Answer 6

Patients ≥6 years who have at least ONE copy of the F508del CFTR mutation or one of 177 other approved mutations