CF- Ivacaftor DI Flashcards
1
Q
Ivacaftor brand name
A
Kalydeco
2
Q
Ivacaftor MoA
A
Facilitates opening of the chloride channel
3
Q
Is ivacaftor a CFTR potentiator or corrector?
A
Potentiator
4
Q
What class CF mutations does ivacaftor work on?
A
Class III and Class IV
5
Q
Ivacaftor indication
A
Patients ≥4 months with ≥1 of 97 ivacaftor-responsive CFTR mutations
6
Q
CF Class III mutation
A
CFTR protein is created and gets to the cell surface, but the channel doesn’t open
7
Q
CF Class IV mutation
A
Opening in the CFTR protein ion is faulty
8
Q
Ivacaftor, along with all other CFTR modulators, must be taken with what?
A
High-fat meal
9
Q
When to dose adjust for ivacaftor (and all CFTR modulators)
A
Moderate-severe hepatic dysfunction
10
Q
Benefits of CFTR modulators in CF
A
Improve QoL, decrease APEs, decrease morbidity and mortality
