Drug Distribution Flashcards
1
Q
What are the factors that affect drug distribution?
A
CO & blood flow Plasma protein binding Lipid solubility Drug ionisation pH of compartments Capillary permeability
2
Q
Out of the factors listed in the previous question, which is the one that INITIAL drug distribution is heavily dependant on?
A
Blood flow
3
Q
What is albumin?
A
The predominate plasma binding protein
4
Q
How do lipid soluble drugs and weak acids respectively, bind to albumin?
A
Non-specificlly
Specifically to a saturable site
5
Q
What property can some drugs have which can prevent them from crossing the cell membrane?
A
Ionised
6
Q
How is the apparent volume of distribution of a drug calculated (Vd)?
A
Total amount of drug in the body/Blood plasma concentration of drug
