Drug Distribution Flashcards
1
Q
Can drugs that bind to proteins reach their sites of action?
A
No. Only unbound drugs can.
2
Q
What factors affect drug distribution?
A
Plasma protein binding Tissue perfusion Membrane characteristics (eg blood brain barrier) Transport mechanisms Disease/Other drugs Elimination
3
Q
Name 3 ways drugs are excreted by the kidneys
A
Glomerular Filtration
Passive tubular re absorption
Active Tubular secretion
