Drug action Flashcards
What is drug action
Living organisms are chemical machines
Rely on chemical signalling with and between cells
Therapeutic agents allow us to interfere with these processes
Why does veterinary pharmacology have added complication
Due to biological diversity of species
Pharmacology definiton
Study of drug action on a living system
Pharmacokinetics
What the body does to the drug
Absorption, distribution, metabolism, excretion
Pharmacodynamics
What the drug does to the body
That factors can be part of translocation
Site of administration
How it is distributed around the body
Site of action
What are the three routes of administration
External- oral and rectal
Topical- skin, cornea, vagina, nasal mucosal
Parenteral- injection, inhalation, sublingual
Considerations when administering a drug
Diversity of species
Research animals
Body size
Cost
Cooperation
Wild animals
Herd treatment
Prevention
Conditions
Reptiles, bird, fish etc.
Enteral dosage forms
Solution
Suspension
Emulsion
Paste
Tablet
Capsule
Powder
Granule
Premix
Medicated block
Parenteral dosage forms
Solution
Suspension
Emulsion
Implants
Dry powder
Intramammary infusion products
Intravaginal delivery systems
Topical
Dusting powder
Cream
Ointment
Paste
Solution
Suspoemulsion
Emulsifiable concentrate
Specialised drug delivery for parasite control
Spot on
Backliner
Handjetting
Hand spraying
Insecticidal collars
Ear tags
What is selective toxicity
The property of a toxic agent to harm/ eradicate one species without affecting the other
Translocation in regards to selective toxicity
Volume of distribution
The blood brain barrier
Body fluid components
Partition into body fat
Plasma protein binding
PH and ion trapping
Two possibilities of drug transfer is
Bulk flow transfer
Diffusional transfer
