Action potiential Flashcards

1
Q

What causes a change in membrane potiential

A

A change in voltage gated channel activity

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2
Q

How does an action potiential work

A

It is triggered when a cell reaches threshold

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3
Q

What happens in milk fever cows?

A

Calcium concentration decreases in the extracellular fluid, this will elevate the resting membrane potiential of the cell in a calcium deficient cow. If resting membrane potiential is increased enough it will exceed threshold which means action potientials will be triggered which causes excitability and unpredictable movement.

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4
Q

Movement of action potientials is facilitated by

A

Positive charge on outside of cell membrane and negative charge on inside of cell membrane

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5
Q

What happens when an action potiential moves through the membrane

A

Current loops are repeated on other areas of the membrane and flips back to initial point of depolarisation then it hits a point in the membrane which is sitting in its absolute refractory period so you cant stimulate another action potiential.

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6
Q

What part of a neuron has high conc of sodium and potassium channels

A

Axon hillock

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7
Q

What part of the cell is most likely to fire an AP

A

Axon hillock.

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8
Q

What do u need in order to form a current loop

A

Separation of charge in the membrane

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9
Q

What is myelination

A

When a neuron is insulated around the axon, cant form a current loop

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10
Q

What are the gaps between insulated layers called

A

Nodes of ranvier

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11
Q

What are nodes of ranvier

A

Breaks in the myelination and the separation of charge across the cell membrane so can form a current loop

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12
Q

What is saltorary conduction?

A

When an action potiential is formed at gaps, it will depolarise that node of ranvier and then jump to the next one and depolarise that and this happens in both directions which means it is bidirectional

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13
Q

What is the advantage of saltatory conduction

A

Faster transmission and preserves energy

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14
Q

Divergent pathway

A

One neuron passes information to multiple neurons

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15
Q

Convergent pathway

A

When multiple neurons pass info to one neuron

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16
Q

What are gap junctions

A

Electrical synapses when there is direct passage of charge between 2 cells

17
Q

What are excitable cells

A

Nerve and muscle

18
Q

How does an action potiential through a neuron start

A
  1. Take an AP and then need to convert electrical signal to chemical then back to electrical
  2. In terminal of [presynaptic cells, there is synaptic vesicles which contain a neurotransmitter. On post synaptic cells there is receptors
19
Q

Pathway if action potiential through a neuron

A

1.Move from axon hillock down to terminal, a terminal there is a large amount of voltage gated CALCIUM channels, this changes membrane potiential
2. Calcium voltage gated channels open
3. There is calcium sitting in the ECF at a higher concentration than ICF.
4. Calcium moves into the cell
5. Due to calcium increase in the cell, vesicles containing neurotransmitters move to specific docking sites on the cell membrane
6. Neurotransmitter is released and diffuses across the synaptic cleft
7. The NT then binds to receptors on the post synaptic cell. These receptors can either be iron channels or linked to iron channels.
8.when NT binds to receptor this causes a change in membrane permeability which allows ions to be transported across the membrane.
9. Sodium channels open and this causes depolarisation to occur

20
Q

How are neurotransmitters removed from a synapse

A

Diffusion
Reuptake
Enzyme degradation

21
Q

Inhibitory post synaptic potiential

A

When NT can close sodium channels and cause hypopolarisation which brings cell away from threshold

22
Q

How many excitatory signals are needed to form an action potiential

A

20

23
Q

Size of graded potiential depends on

A

Number of neurotransmitter
Number of receptors

24
Q

Temporal summation is

A

One place on the membrane over time

25
Q

Spatial summation

A

At one time over the whole membrane

26
Q

Can spatial and temporal summation happen at the same time

A

Yes