Dr O Quiz 3 - ch 33

Question 0

How Amyotrophic lateral sclerosis happen in the body?

What role does oxidative damage play?

Answer 0

Degeneration and scarring of motor neuron in lateral aspect of spinal cord, brainstem and cerebral cortex
Damages nerve cells

Question 1

What is a major component of neurodegenerative disease?
What happens to a cell that is undergoing this process?
What happens if this is not lethal?

Answer 1

Cellular stress
Cytoskeleton collapse, peri nuclear bundle Or clumps of protein aggregates form
The cell Adapts by forming intracellular inclusions

Question 2

Clinical manifestations of ALS

Answer 2

Cognitive impairment
Asymmetric weakness
Trouble with Articulation, chewing, and swallowing
Dysarthria - drooling

Question 3

Pseudobulbar palsy reflects damage where in the body?

Answer 3

Corticobulbar tract, cranial nerve involvement

Question 4

What is the difference between multiple sclerosis and ALS?

Answer 4

MS is characterized by sclerotic plague disseminated through the CNS, while ALS is a progressive motor neuron disease

Question 5

What is Alzheimer’s disease?

Answer 5

Progressive dementia or decline in intellectual functions severe enough to interfere with the persons relationships and ability to carry out daily activities

Question 6

What a the clinical manifestations of Alzheimer’s disease?

Answer 6

Subtle personality changes
Memory loss
Abnormal motor signs

Question 7

Warning signs of Alzheimer’s disease

Answer 7

Memory loss, difficulty performing familiar task, simple language, disoriented, decreased judgement, abstract thinking problem, misplacing things, change in mood, personality changes, loss of initiative

Question 8

DYstonia leads to hypertrophy of what muscle?
What happens during blepharospasm, another symptom of DYstonia?
What may increase the symptoms?

Answer 8

SCM
Uncontrolled blinking of the eyelid from seconds to hours
Aggressive strenghtening

Question 9

What are distinguishing characteristics of huntingtons disease?

Answer 9

Abnormalities of movement
Personality disturbance/dementia
Choreatic movement

Question 10

Clinical manifestations of multiple sclerosis

Answer 10

Progressive disability over time
Optic neuritis
Lesion in spinal cord
Sensory changes
Fatigue, mid afternoon motor weakness, mental fatigue sleepiness

Question 11

Definition of Parkinson’s disease

Answer 11

Chronic progressive disease of CNS characterized by rigidity, tremor, Bradykinesia and postural instability from complex interaction between multiple predisposing gene and environmental affects

Question 12

Dopamine levels at which parts of The brain are affected during Parkinson’s disease (3)

Answer 12

Substantia niagra, globus pallidus, and midbrain

Question 13

What are the clinical manifestations of Parkinson’s disease? (4)

Answer 13

Ridigity
Bradykinesia
Gait is narrow based and shuffling
Posture is kyphosis and flexion

Question 14

What medication is used in people with Parkinson’s disease?

What condition involving the legs is involved with Parkinson’s disease

Answer 14

Levodopa

Restless leg syndrome