dose response interactions 2 (class) Flashcards
the therapeutic window is is ? whereas the therapeutic index is?
- temporal
- descriptive
the therapeutic window describes the level of a drug as a function of? and it works to maintain?
- time
- effectiveness
what is the equation for the therapeutic index?
lethal dose @ 50%/ effective dose @ 50%
the therapeutic index has to do with how? a drug is
- safe
what do you doctors use so they know how to prescribe?
therapeutic index
the therapeutic index is the area between the dosage that gives what 2 effects?
- between the therapeutic effect and the toxic effect
the therapeutic index is used for? (2)
- commercial development
2. dissemination
what is the “safety ratio”
the amount of drug you can have without dying
safety ratio is used for? (2)
- recreational use
- effective dose produces the desired effect
what does the protective index look at?
how many people die vs how many ppl use it
–> how safe the drug is
the protective index is (descriptive or temporal)
descriptive
equation for protective index (how much of the antidote will be given to the person)
LD(50%) (A+B)/ LD (50%)A
A= the toxin
B= non toxic substance
reserved for human consumption and more pragmatic (higher fidelity)
- what is this?
protective index
the protective index is sometimes considered a ? for humans
TI
when is the only time TD and LD don’t mean the same thing
protective index
