DM Flashcards

1
Q

4 ways to Dx DM?

A
  • Fasting glucose > 126
  • OGTT (2 hour with 75 g oral glucose tolerance) > 200
  • Sx + random glucose > 200
  • A1c > 6.5
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2
Q

4 ways to Dx Pre-DM

A
  • Fasting glucose 100-125
  • OGTT (2 hour with 75 g): 140-199
  • A1c 5.7-6.4
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3
Q

Recall: cut-off for Dx using a1c

A
  • DM: 6.5

- IFG/pre-DM: 5.7-6.4

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4
Q

Recall: cut-off for Dx using OGTT

A
  • DM: > 200

- IFG/pre-DM: 140-199

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5
Q

Recall: cut-off for Dx using fasting glucose

A
  • DM: > 126

- IFG/pre-DM: 100-125

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6
Q

If no risk factors, when start screening for DM?

A

Both genders: > 45 yo

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7
Q

What are risk factors of DM?

A
  • physical inactivity
  • Fam hx
  • Race (non-white)
  • Women who has baby > 9lb or Hx of GDM
  • HTN or on anti-HTN therapy
  • HDL 250
  • PCOS
  • a1c > 5.7 in previous testing
  • acanthosis nigricans
  • CVD
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8
Q

What start screening a$ patient for DM?

A

BMI > 25 + one risk factor

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9
Q

If screening test is normal, repeat in ___ years?

A

3

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10
Q

What is following up schedule for well-controlled patient?

A

Biannually - 2 times a year

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11
Q

schedule for poorly-controlled patient with changing target?

A

Quarterly

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12
Q

What’s the DM sx in the elderly?

A

Confusion and Dehydration

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13
Q

T of F: renal threshold for glucose increases with advanced age

A

T

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14
Q

T of F: with elderly, decreased thirst will suppress presentation of polydipsia

A

T

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15
Q

T of F; elderly has diminished glucagon, epinephrine, growth hormone response to low glucose

A

T

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16
Q

What is the DM treatment goal for healthy elderly adult with life expectancy greater than 10 years?

A
17
Q

What is the DM treatment goal for frail olderly adult with comorbidities and life expectancy less than 10 years

A

7-8

18
Q

For patient with CKD, treatment goal is

A
19
Q

Elderly complications of DM

A
  • mononeuropathy: isolated CN 3 nerve palsy common

- Hypoglycemic increases risk of dementia and worsens cognitive impairment

20
Q

T of F: avoid metformin in anorexia, renal impariment, and CHF pateints

A

T

21
Q

T of F: avoid thiazolidinediones in CHF patients

A

T

22
Q

What are the drugs used in two-drug combo for DM Rx?

A
  • sulfonylurea
  • thiazolidinedione
  • DPP-4
  • GLP-1 receptor agonist
  • Insulin
23
Q

What are major ADR of sulfonylurea

A
  • mod risk of hypoglycemia

- weight gain

24
Q

What are major ADR of thiazolidinedione

A
  • low risk of hypoglycemia
  • weight gain
  • Edema, HF, Fx
25
Q

What are major ADR of DPP-4 inhibitor

A
  • low risk of hypoglycemia
  • weight neural!
  • rare side effect
  • pricey $$$
26
Q

What are major ADR of GLP-1 agonist?

A
  • low risk of hypoglycemia
  • weight loss!!!
  • GI side effect
  • pricey $$$
27
Q

Can do up to three-drug combo, then what?

A

insulin

28
Q

Which drug is weight neural?

A

DPP-4 inhibitor

29
Q

What are examples of DPP-4 inhibitor?

A

Sitagliptin (Januvia)

Saxagliptin, Alogliptin,

30
Q

Which drug actually helps to lose weight?

A

GLP-1 receptor agonist

31
Q

What are examples of GLP–1 receptor agonist?

A

Exenatide, Albiglutide

32
Q

Which drug is known for causing edema, HF, Fx?

A

Thiazolidinedione

33
Q

Examplse of thiazolidinedione

A

‎Pioglitazone · ‎Rosiglitazone

34
Q

Which drug has higher dose of causing hypoglycemia than others?

A
  • Most is insulin

- Then sulfonylurea

35
Q

What are examples of sulfonylurea?

A

‎Gliclazide · ‎Glimepiride · ‎Glipizide

36
Q

Which drug acts by increased insulin release from pancreas beta cell?

A

Sulfonylurea

37
Q

How does Thiazolidinedione work?

A

Activating PPAR gamma - peroxisome proliferator activated receptors - nuclear receptor for gene transcription -> increase storage of fatty acids in adipocytes