Diuretics Flashcards
Loop Diuretics location
thick ascending Loop/Loop of Henle: most potent
Loop Diuretics MOA
Inhibits luminal Na,K, Cl transporter
More Na, K, Cl delivered downstream (Mg and Ca impacted)
Water follows Na
Loop Diuretic Use
Hypertension, CHF, Edema, Pulmonary Edema, Renal Disease
Loop Diuretic ADR
HYPO K+ HYPO Ca HYPO Mg Hyperuricemia Hypervolemia Mild hyperglycemia Ototoxic
Loop Diuretic Drugs
Furosemide
Torsemide
Bumetanide
Ethacrynic acid
Thiazide Diuretic location
Distal Convoluted Tubule
Thiazide Diuretic MOA
Inhibit NaCl luminal transporter
Na, Cl remain in lumen/urine, water follows
Thiazide Diuretic uses
Initial hypertension use
ineffective in eCrCl <30 (except metolazone)
For edema and CHF
Increase Ca reabsorption (treats kidney stones from hypercalciuria)
Thiazide Diuretic ADRs
Hypo K Hypercalcemia Hypo Mg Hyperuricemia Hyperglycemia Hypovolemia Hypotension
Thiazide Diuretic Drugs
Hydrochlorothiazide Chlorothalidone Metolazone Indapamide Chlorothiazide
K Sparing Diuretic: Location
Collecting Duct
K Sparing diuretic: Aldosterone Antagonist drugs
Spironolactone and Eplerenone
K Sparing AA: MOA
Inhibits binding of aldosterone
Reduced Na/H2O reabsorption
Increased K reabsorption
K sparing AA: use
CHF, HTN, MI (E>S)
Hyperaldosteronism (S>E)
K sparing AA: ADR
Hyperkalemia
steroid related ADRs (S>E)
