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Pharmacology I: Exam 2 > adrenergics and antiadrenergics: betas 1+2 agonists and antagonists > Flashcards

adrenergics and antiadrenergics: betas 1+2 agonists and antagonists Flashcards

1
Q

What do selective beta 1 agonist do to the SA node?

A

increases sinus rate, treats bradycardia

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2
Q

What do selective beta 1 agonists do to the AV node?

A

increases AV nodal conduction, treats heart block and cardiac arrest

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3
Q

What do selective beta 1 agonists do to the atria/ventricles?

A

increases FOC and SV, treats acute heart failure

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4
Q

what do selective beta 1 agonist do to the kidneys?

A

increases renin release, treats hypotension

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5
Q

Selective beta 1 agonist: Dobutamine

A

increases Force of Contraction; used for cardiogenic shock and acute congestive heart failure

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6
Q

Non selective beta 1 agonist: Isoproterenol

A

increases force of contraction

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7
Q

what do selective beta 1 antagonists do to SA node?

A

decreases sinus rate; treats tachycardia and angina

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8
Q

what do selective beta 1 antagonists do to AV node?

A

decreases AV nodal conduction; treats arrhythmias

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9
Q

what do selective beta 1 antagonists do to the atria/ventricles?

A

decreases FOC and SV; treats post MI, chronic heart failure, angina, arrythmias

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10
Q

what do selective beta 1 antagonists do to the kidneys

A

decreases renin release, treats hypertension

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11
Q

Selective Beta 1 antagonist drugs

A

Metoprolol succinate, Atenolol, Nebivolol, Bisoprolol, Acebutolol, Betaxolol, Esmolol

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12
Q

Nebivolol and Bisoprolol selectivity

A

They stay selective even at high doses

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13
Q

what do selective beta 2 agonists do to bronchial smooth muscle?

A

relaxation and bronchodilate; treats asthma, COPD and bronchospasms

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14
Q

what do selective beta 2 agonist do to the uterine smooth muscle?

A

relaxation, prevents premature labor

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15
Q

what do selective beta 2 agonists do to the vascular smooth muscle?

A

vasodilation (insignificant)

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16
Q

what do selective beta 2 agonists do to the skeletal muscle?

A

vasodilation (insignificant)

17
Q

what do selective beta 2 agonists do to the liver?

A

glycogenolysis, gluconeogenesis

18
Q

what do selective beta 2 agonists do to the eye?

A

increase aqueous humor production

19
Q

Selective Beta 2 agonist drugs: SABA

A

albuterol and levalbuterol

20
Q

Selective Beta 2 agonist drugs: LABA

A

Formoterol, Salmeterol, Olodaterol, Arformoterol, Indacaterol

21
Q

Nonselective beta 2 agonist: metaproterenol

A

beta 2 effect for asthma, COPD, and bronchospasms

22
Q

What do beta 2 antagonist do to bronchial smooth muscle?

A

contraction and bronchoconstriction

23
Q

what do beta 2 antagonists do to uterine smooth muscle?

A

contraction

24
Q

what do beta 2 antagonists do to vascular smooth muscle?

A

vasoconstriction (insignificant)

25
Q

what do beta 2 antagonists do to skeletal muscle?

A

decreases glycogenolysis; treats tremors

26
Q

what do beta 2 antagonists do to the liver?

A

decrease portal venous pressure; treats hypertension and portal venous pressure

27
Q

what do beta 2 antagonists do to the eye?

A

decreases aqueous humor production; treats glaucoma

28
Q

non selective beta antagonist: Nadolol

A

decreases portal venous pressure, treats esophageal varices bleeding prophylaxis

29
Q

nonselective beta antagonist: Propanolol

A

migraine prophylaxis, tremors, stage fright

30
Q

non selective beta antagonists: carteolol, timolol, levobunolol, metipranolol

A

decrease aqueous humor

31
Q

non selective beta antagonist: sotalol

A

anti arrhythmic

32
Q

non selective beta antagonist: pindolol

A

general beta antagonist functions

33
Q

Therapeutic uses for non selective beta antagonists

A

glaucoma, ocular hypertension, migraine prophylaxis, tremors, stage fright, hypertension, atrial fibrillation, arrhythmias, portal hypertension, esophageal varices bleeding prophylaxis

34
Q

What does beta 3 agonist do for bladder, prostate, and urethra?

A

relaxation of detrusor muscle to store urine better

35
Q

selective beta 3 agonist: Mirabegron

A

increases bladder capacity during storage phase

36
Q

ADR of Mirabegron

A

Increase in BP and HR, may lose selectivity at high doses

Pharmacology I: Exam 2 (10 decks)

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