adrenergics and antiadrenergics: betas 1+2 agonists and antagonists Flashcards
What do selective beta 1 agonist do to the SA node?
increases sinus rate, treats bradycardia
What do selective beta 1 agonists do to the AV node?
increases AV nodal conduction, treats heart block and cardiac arrest
What do selective beta 1 agonists do to the atria/ventricles?
increases FOC and SV, treats acute heart failure
what do selective beta 1 agonist do to the kidneys?
increases renin release, treats hypotension
Selective beta 1 agonist: Dobutamine
increases Force of Contraction; used for cardiogenic shock and acute congestive heart failure
Non selective beta 1 agonist: Isoproterenol
increases force of contraction
what do selective beta 1 antagonists do to SA node?
decreases sinus rate; treats tachycardia and angina
what do selective beta 1 antagonists do to AV node?
decreases AV nodal conduction; treats arrhythmias
what do selective beta 1 antagonists do to the atria/ventricles?
decreases FOC and SV; treats post MI, chronic heart failure, angina, arrythmias
what do selective beta 1 antagonists do to the kidneys
decreases renin release, treats hypertension
Selective Beta 1 antagonist drugs
Metoprolol succinate, Atenolol, Nebivolol, Bisoprolol, Acebutolol, Betaxolol, Esmolol
Nebivolol and Bisoprolol selectivity
They stay selective even at high doses
what do selective beta 2 agonists do to bronchial smooth muscle?
relaxation and bronchodilate; treats asthma, COPD and bronchospasms
what do selective beta 2 agonist do to the uterine smooth muscle?
relaxation, prevents premature labor
what do selective beta 2 agonists do to the vascular smooth muscle?
vasodilation (insignificant)
what do selective beta 2 agonists do to the skeletal muscle?
vasodilation (insignificant)
what do selective beta 2 agonists do to the liver?
glycogenolysis, gluconeogenesis
what do selective beta 2 agonists do to the eye?
increase aqueous humor production
Selective Beta 2 agonist drugs: SABA
albuterol and levalbuterol
Selective Beta 2 agonist drugs: LABA
Formoterol, Salmeterol, Olodaterol, Arformoterol, Indacaterol
Nonselective beta 2 agonist: metaproterenol
beta 2 effect for asthma, COPD, and bronchospasms
What do beta 2 antagonist do to bronchial smooth muscle?
contraction and bronchoconstriction
what do beta 2 antagonists do to uterine smooth muscle?
contraction
what do beta 2 antagonists do to vascular smooth muscle?
vasoconstriction (insignificant)
what do beta 2 antagonists do to skeletal muscle?
decreases glycogenolysis; treats tremors
what do beta 2 antagonists do to the liver?
decrease portal venous pressure; treats hypertension and portal venous pressure
what do beta 2 antagonists do to the eye?
decreases aqueous humor production; treats glaucoma
non selective beta antagonist: Nadolol
decreases portal venous pressure, treats esophageal varices bleeding prophylaxis
nonselective beta antagonist: Propanolol
migraine prophylaxis, tremors, stage fright
non selective beta antagonists: carteolol, timolol, levobunolol, metipranolol
decrease aqueous humor
non selective beta antagonist: sotalol
anti arrhythmic
non selective beta antagonist: pindolol
general beta antagonist functions
Therapeutic uses for non selective beta antagonists
glaucoma, ocular hypertension, migraine prophylaxis, tremors, stage fright, hypertension, atrial fibrillation, arrhythmias, portal hypertension, esophageal varices bleeding prophylaxis
What does beta 3 agonist do for bladder, prostate, and urethra?
relaxation of detrusor muscle to store urine better
selective beta 3 agonist: Mirabegron
increases bladder capacity during storage phase
ADR of Mirabegron
Increase in BP and HR, may lose selectivity at high doses
