adrenergics and antiadrenergics: betas 1+2 agonists and antagonists

Question 1

What do selective beta 1 agonist do to the SA node?

Answer 1

increases sinus rate, treats bradycardia

Question 2

What do selective beta 1 agonists do to the AV node?

Answer 2

increases AV nodal conduction, treats heart block and cardiac arrest

Question 3

What do selective beta 1 agonists do to the atria/ventricles?

Answer 3

increases FOC and SV, treats acute heart failure

Question 4

what do selective beta 1 agonist do to the kidneys?

Answer 4

increases renin release, treats hypotension

Question 5

Selective beta 1 agonist: Dobutamine

Answer 5

increases Force of Contraction; used for cardiogenic shock and acute congestive heart failure

Question 6

Non selective beta 1 agonist: Isoproterenol

Answer 6

increases force of contraction

Question 7

what do selective beta 1 antagonists do to SA node?

Answer 7

decreases sinus rate; treats tachycardia and angina

Question 8

what do selective beta 1 antagonists do to AV node?

Answer 8

decreases AV nodal conduction; treats arrhythmias

Question 9

what do selective beta 1 antagonists do to the atria/ventricles?

Answer 9

decreases FOC and SV; treats post MI, chronic heart failure, angina, arrythmias

Question 10

what do selective beta 1 antagonists do to the kidneys

Answer 10

decreases renin release, treats hypertension

Question 11

Selective Beta 1 antagonist drugs

Answer 11

Metoprolol succinate, Atenolol, Nebivolol, Bisoprolol, Acebutolol, Betaxolol, Esmolol

Question 12

Nebivolol and Bisoprolol selectivity

Answer 12

They stay selective even at high doses

Question 13

what do selective beta 2 agonists do to bronchial smooth muscle?

Answer 13

relaxation and bronchodilate; treats asthma, COPD and bronchospasms

Question 14

what do selective beta 2 agonist do to the uterine smooth muscle?

Answer 14

relaxation, prevents premature labor

Question 15

what do selective beta 2 agonists do to the vascular smooth muscle?

Answer 15

vasodilation (insignificant)

Question 16

what do selective beta 2 agonists do to the skeletal muscle?

Answer 16

vasodilation (insignificant)

Question 17

what do selective beta 2 agonists do to the liver?

Answer 17

glycogenolysis, gluconeogenesis

Question 18

what do selective beta 2 agonists do to the eye?

Answer 18

increase aqueous humor production

Question 19

Selective Beta 2 agonist drugs: SABA

Answer 19

albuterol and levalbuterol

Question 20

Selective Beta 2 agonist drugs: LABA

Answer 20

Formoterol, Salmeterol, Olodaterol, Arformoterol, Indacaterol

Question 21

Nonselective beta 2 agonist: metaproterenol

Answer 21

beta 2 effect for asthma, COPD, and bronchospasms

Question 22

What do beta 2 antagonist do to bronchial smooth muscle?

Answer 22

contraction and bronchoconstriction

Question 23

what do beta 2 antagonists do to uterine smooth muscle?

Answer 23

contraction

Question 24

what do beta 2 antagonists do to vascular smooth muscle?

Answer 24

vasoconstriction (insignificant)

Question 25

what do beta 2 antagonists do to skeletal muscle?

Answer 25

decreases glycogenolysis; treats tremors

Question 26

what do beta 2 antagonists do to the liver?

Answer 26

decrease portal venous pressure; treats hypertension and portal venous pressure

Question 27

what do beta 2 antagonists do to the eye?

Answer 27

decreases aqueous humor production; treats glaucoma

Question 28

non selective beta antagonist: Nadolol

Answer 28

decreases portal venous pressure, treats esophageal varices bleeding prophylaxis

Question 29

nonselective beta antagonist: Propanolol

Answer 29

migraine prophylaxis, tremors, stage fright

Question 30

non selective beta antagonists: carteolol, timolol, levobunolol, metipranolol

Answer 30

decrease aqueous humor

Question 31

non selective beta antagonist: sotalol

Answer 31

anti arrhythmic

Question 32

non selective beta antagonist: pindolol

Answer 32

general beta antagonist functions

Question 33

Therapeutic uses for non selective beta antagonists

Answer 33

glaucoma, ocular hypertension, migraine prophylaxis, tremors, stage fright, hypertension, atrial fibrillation, arrhythmias, portal hypertension, esophageal varices bleeding prophylaxis

Question 34

What does beta 3 agonist do for bladder, prostate, and urethra?

Answer 34

relaxation of detrusor muscle to store urine better

Question 35

selective beta 3 agonist: Mirabegron

Answer 35

increases bladder capacity during storage phase

Question 36

ADR of Mirabegron

Answer 36

Increase in BP and HR, may lose selectivity at high doses