Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology I: Exam 2 > ACEI and ARBs > Flashcards

ACEI and ARBs Flashcards

1
Q

Neprilysin Inhibitor: Drugs

A

Sacubitril and Valsartan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Neprilysin Inhibitor MOA

A

Stops degradation of endogenous vasoactive peptides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Neprilysin Inhibitor Effects

A

Vasodilation
Natriuresis
Diuresis
Inhibited pathological growth and fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Neprilysin Inhibitor ADRs

A

Hyperkalemia
cough/angioedema
ARF/AKI
Hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Valsartan (entreso)

A

Reduce risk of CV death and hospitalization
For HF patients with CHF and Reduced EF
ARNI: Angiotensin Receptor Neprilysin Inhibitor
works better than Enalapril

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Angiotensin Converting Enzyme Inhibitors (ACEI)

A 
Lisinopril
Enalapril
Quinapril
Captopril
Ramipril
Benazepril
Fosinopril
Moexipril
Perinopril
Trandolapril
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ACEI MOA

A

inhibits angiotensin converting enzyme, which prevents the formation of angiotensin II, which stops the increase of BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ACEI Therapeutic Use

A 
Hypertension
Post MI
Heart Failure with reduced Ejection Fraction
Chronic Kidney Disease
Decreases Proteinuria (Renal protection)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ACEI ADRs

A 
Dry cough and Angioedema from bradykinin buildup
Hyper K+
Acute Renal Failure
Teratogenic
Reduced efficacy in African Americans
AFI/AKI in starting medication
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Direct Renin Inhibitor

A

Aliskiren

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Aliskiren MOA

A

Competitive enzyme inhibitor, prevents generation of angiotensin I (stops renin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Aliskiren Therapeutic Use

A

Comparable BP reduction to ACEI/ARB in HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Aliskiren ADR

A 
Hypotension
Hyper K+
ARF/AKI
Rare angioedema
teratogenic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Aliskiren Contraindications

A

Don’t combine with ACEI/ARB (especially in Diabetes II) , it will worsen above symptoms and increase risk of angioedema, stroke, and MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Angiotensin Receptor Blockers (ARBs) Drugs

A 
Losartan
Valsartan
Olmesartan
Irbesartan
Candesartan
Telmisartan
Eprosartan
Azilsartan
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ARBs MOA

A

Blocks receptors for Angiotensin II (prevents vasoconstriction and aldosterone secretion) to lower BP

17
Q

ARBs Therapeutic Uses

A 
Hypertension
Post MI
Heart Failure
CKD
Renal Protection
18
Q

ARBs ADRs

A 
Lower incidence for cough and angioedema
High K+
ARF/AKI
Teratogenic
Reduced efficacy in African Americans

Pharmacology I: Exam 2 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions