Adrenergics- sympatholytics and mimetics

Question 1

Non Amphetamine uses

Answer 1

ADHD, Obesity, Narcolepsy, Binge Eating

Question 2

ADRs for Non Amphetamines

Answer 2

Less pronounced than Amphetamines: Increased SBP/DBP, tachycardia, reduced appetite, weight loss, dry mouth, teeth grinding, abdominal pain, insomnia

Question 3

Non Amphetamines: Drugs

Answer 3

Methylphenidate and Dexmethylphenidate

Question 4

Amphetamines MOA

Answer 4

promotes the release of NE and DA from presynaptic storage, blocks NE/DA reuptake

Question 5

Amphetamine Uses

Answer 5

ADHD, Obesity, Narcolepsy, and Binge Eating

Question 6

Amphetamine Drugs

Answer 6

Amphetamines, Dextroamphetamines, Lisdexamfetamines, Methamphetamines

Question 7

Amphetamines ADRs

Answer 7

inceased SBP/ DBP, tachycardia, lost/reduced appetite, weight loss, dry mouth, teeth grinding, abdominal pain, insomnia

Question 8

indirect Sympathomimetic: Cocaine

Answer 8

inhibits reuptake of NET in various locations

Question 9

Indirect Sympatholytic: Metyrosine

Answer 9

Inhibits tyrosine hydroxylase to prevent conversion of tyrasine to dopamine; beneficial for pheochromocytoma

Question 10

Indirect Sympatholytic: Reserpine

Answer 10

inhibits VMAT to prevent dopamine storage; used as a hypertensive

Question 11

indirect sympathomimetic: Atomoxetime

Answer 11

involved in NET reuptake inhibition; good for kids with ADHD

Question 12

indirect sympathomimetic: Modafinil

Answer 12

increases concentrations of NorEpi, Dopamine, Seratonin and glutamate and decreases GABA; used for narcolepsy and circadian rhythm disturbances

Question 13

Labetalol and Carvedilol

Answer 13

Used to reduce BP and HR, Could cause reflex tachycardia, , labetolol is great for pregnancy hypertension

Question 14

Epinephrine

Answer 14

used for Anaphylaxis, constricts vessels and increases BP, used to prolong local anesthetics

Question 15

Dopamine uses

Answer 15

good for severe CHF with fluid overload
increases urine output
hemodynamic support: cardiogenic or septic shock

Question 16

Low Dose Dopamine

Answer 16

D1 receptor activation, increases diuresis

Question 17

Moderate Dose Dopamine

Answer 17

added beta 1 activation; increased cardiac and renal benefit

Question 18

High Dose Dopamine

Answer 18

add alpha 1 activation, less D1; vasocontriction, increases SBP/DBP, loss renal benefit