Calcium Channel Blockers

Question 1

Dihydropuridine (DHP) Drugs

Answer 1

Amlodipine, Nifedipine, Nicardipine, Felodipine, Isradipine, Nimodipine, Nisoldipine

Question 2

DHP MOA

Answer 2

Blocks Ca channel on vascular smooth muscle/arteries which results in vasodilation: reduce BP

Question 3

DHP Effects

Answer 3

selective, vasodilate arteries, minimal cardiac effect, not an antiarrhythmic

Question 4

DHP ADRs

Answer 4

Reflex Tachycardia, peripheral edema, flushing, palpitations, hypotension, dizziness, fatigue

Question 5

DHP therapeutic uses

Answer 5

Hypertension treatment, vasodilation, reduce BP

Question 6

Precautions for DHP

Answer 6

Risk of exacerbating angina, precipitating arrhythmias

Question 7

Non DHP: Verapamil

Answer 7

non selective, vasodilates, decreases HR and BP

Question 8

Non DHP ADR

Answer 8

Constipation, dizziness, drug induced arrythmias, AV block, sinus bradycardia, ventricular fibrillation

Question 9

Non DHP therapeutic uses

Answer 9

used for angina, increases oxygen supply and decreases oxygen demand, class IV antiarrhythmic

Question 10

Non DHP: Diltiazem

Answer 10

non selective, vasodilation, decreases BP and HR, less constipation, flushing, rhinitis

Question 11

Precaution with Non DHP

Answer 11

do not use on patients with Congestive HF or with beta blockers, or those with preexisting av block, pulmonary edema, and precipitating arrhythmias