adrenergics and anti adrenergics: the Alpha drugs

Question 1

what does Alpha 1 agonist do to vascular smooth muscle?

Answer 1

Vasoconstriction; treats hypotension

Question 2

what does Alpha 1 agonist do to the nasal mucosa

Answer 2

Vasoconstriction; treats nasal congestion

Question 3

what does Alpha 1 agonist do the bladder, urethra, and prostate?

Answer 3

Contraction

Question 4

what does Alpha 1 agonist do to the Eye?

Answer 4

Vasoconstriction; treats Hyperemia/red eye, reduces intraoccular pressure

Question 5

Selective Alpha 1 Agonist: Midodrine

Answer 5

treats orthostatic hypotension

Question 6

Selective Alpha 1 Agonist: Phenylephrine

Answer 6

for cold/cough; IV vassopressor; eye drops; will raise BP

Question 7

Selective Alpha 1 Agonist: Oxymetazoline

Answer 7

nasal spray; rhinitis medicamentosa (rebound congestion)

Question 8

Selective Alpha 1 Agonist: Naphazoline

Answer 8

eye drops for red eye

Question 9

What does alpha 1 antagonist do to the vascular smooth muscle?

Answer 9

vasodilation; treats hypertension

Question 10

what does alpha 1 antagonist do to the nasal mucosa?

Answer 10

vasodilation

Question 11

what does alpha 1 antagonist do to the bladder, urethra, and prostate?

Answer 11

relaxation; treats benign prostate hyperplasia

Question 12

what does alpha 1 antagonist do to the eye?

Answer 12

vasodilation; miosis

Question 13

Selective Alpha 1 Antagonist: Prazosin

Answer 13

used for PTSD nightmares; least selective

Question 14

Selective Alpha 1 Antagonist: Doxazosin and Terazosin

Answer 14

Blocks all alpha 1 subtypes; used to BPH and HTN

Question 15

Selective Alpha 1 Antagonist: Tamulosin and Alfuzosin

Answer 15

Selective for alpha 1a on prostate/urethra. used for BPH

Question 16

Selective Alpha 1 Antagonist: Silodosin

Answer 16

Most selective for alpha 1a, used for BPH; least hypotensive

Question 17

ADRs of Alpha 1 Antagonists

Answer 17

Erectile dysfunction, Abnormal Ejaculation, Dizziness, Syncope, Hypotension, Reflexive Tachycardia, First Dose Phenomenon

Question 18

What do selective alpha 2 agonists do to the CNS?

Answer 18

Decreases SANS outflow; treats HTN, ADHD, Withdrawal, Sedation, Muscle Spasticity

Question 19

What do selective Alpha 2 Agonists do to SANS nerve ending?

Answer 19

Decreases NE release; treats HTN, ADHD, withdrawal, sedation, muscle spasticity

Question 20

what do selective Alpha 2 agonist do to the eye?

Answer 20

Decrease aqueous humor production; treats glaucoma

Question 21

Selective Alpha 2 agonist: Clonidine and Tizanidine

Answer 21

Used for HTN, ADHD, withdrawal, muscle spasticity

Question 22

Selective Alpha 2 agonist: Guanfacine

Answer 22

ADHD old medication

Question 23

Selective Alpha 2 agonist: Dexmedetomide

Answer 23

promotes sedation

Question 24

Selective Alpha 2 agonist: Brimonide and Apraclonidine

Answer 24

eye drops for glaucoma

Question 25

Selective Alpha 2 agonist: Methyldopa

Answer 25

For Hypertension in pregnancy

Question 26

What do non selective alpha antagonist do?

Answer 26

they vasodilation everything and increase cardiac output

Question 27

What does non selective alpha antagonist treat?

Answer 27

pheochromocytoma

Question 28

ADRs of non selective alpha antagonists

Answer 28

nasal congestion, miosis, orthostatic hypotension

Question 29

Non selective Alpha Antagonists: Phenoxybenzamine and Phentolamine

Answer 29

treatment of extravastation from IV alpha 1 agonists