DISEASES AFFECTING DENTISTRY Flashcards
what is anaemia and what are its main causes?
a reduction of Haemoglobin (oxygen carrying ability) in the blood
- reduced production of RBCs
- increased losses (excessive bleeding)
- increased demand of body
what are examples of iron sources?
- meat
- green leafy vegetables
- iron tablets
what are the main types of anaemias?
- iron deficiency anaemia
- folate deficiency anaemia
- vitamin B12 anaemia/pernicious anaemia
- haemolytic anaemias
what diseases may cause iron-definiciency anaemia? why?
BLOOD LOSS
- menstruation, pregnancy and GI tract bleeding
ACHLORHYDRIA
- lack of stomach acid therefor no conversion of non-haem iron to haem
COELIAC DISEASE
- intestinal villi abnormality which lowers absorption of iron from diet
how can iron-loss anaemia occur?
- gastric erosions and ulcers
- GI tract bleeding (inflammatory bowel disease, bowel cancer etc)
- haemorrhoids
ANYTHING THAT CAUSES BLEEDING
how is vitamin B12 abosorbed within the body?
- intrinsic factor secreted by gastric parietal cells
- intrinsic factor then binds to vitamin B12 taken in through diet
- absorbed specifically in ILEUM
- stored usually in liver
how can Vitamin B12 anaemia occur?
- lack of B12 intake (VEGANS)
- lack of intrinsic factor (specific autoimmune disease known as pernicious anaemia)
- disease of terminal ileum (chrons disease)
anaemia in a patient may be as a result of abnormal globin chains, what are examples of these conditions?
- Thalassaemia
- Sickle cell anaemia
how can the haem production in thalassaemic patients be described?
NORMAL
- disease occurs due to genetic mutation of globin chains
what are the clinical effects of thalassaemia?
- chronic anaemia
- marrow hyperplasia (bones expand)
- splenomegaly
- cirrhosis
- gallstones
how do RBCs differ in a patient with sickle cell anaemia?
RBCs have curled up edges, no longer able to squeeze through capillaries
what is pernicious anaemia?
a specific type of Vitamin B12 definciency anaemia caused by lack of intrinsic factor
what are microcytic cells? what type of anaemias have thsi?
RBCs that are smaller than normal
- iron deficiency anaemia
- thalassaemia
what are macrocytic cells? what type of anaemias exhibit this?
RBCs which are larger in size
- B12/folate deficiency anaemia
what are normocytic cells? what types of anaemia may show these?
normal sized RBCs
- usually normocytic anaemias are caused by bleeding, renal problems are chronic diseases