DIS - Overview of Ocular Inflammation - Week 6 Flashcards
Define uveitis. Is it intraocular only?
Inflammation of any part of the uveal tract
Intraocular only
Between granulomatous and non-granulomatous uveitis, which is chronic and acute?
Non-granulomatous - acute
Granulomatous - chronic
What is injection like between granulomatous and non-granulomatous uveitis?
Non-granulomatous - high grade
Granulomatous - low grade
What is pain like between granulomatous and non-granulomatous uveitis?
Non-granulomatous - high grade
Granulomatous - low grade to none
What is the presence of nodules like between granulomatous and non-granulomatous uveitis?
Non-granulomatous - none
Granulomatous - present
What is the appearance of keratic precipitates like between granulomatous and non-granulomatous uveitis?
Non-granulomatous - small/fine
Granulomatous - mutton fat
What is the appearance of fundus pathology like between granulomatous and non-granulomatous uveitis?
Non-granulomatous - diffuse
Granulomatous - nodular lesions
What are the main cell types present in granulomatous (2) and non-granulomatous uveitis (2)?
Non-granulomatous
-neutrophils
-lymphocytes
Granulomatous
-macrophages
-giant cells
What cells appear first in most forms of inflammation?
Neutrophils
Are the capillaries of the iris fenestrated?
No
What junctions are found between endothelial cells of the iris capillaries?
Tight junctions
Does the iris stroma have a surface epithelium?
No
-capillary leakage is directly into the aqueous
What junctions are present in the pigmented and non-pigmented epithelium of the iris?
Non-pigmented - tight junctions
Pigmented - gap junctions
What happens to tight junctions during inflammation and what happens after the inflammation resolves?
Destroyed with inflammation
Replaced after it resolves
What is the key marker for inflammation?
Cells
Is there a potential for permanent damage to the blood aqueous barrier with constant inflammation?
Yesd
What are four common causes of uveitis in young individuals (including adolescents)?
JIA
Leukaemia/lymphoma
Retinoblastoma
Toxocariasis
What are eleven common causes of uveitis in young to middle aged individuals?
Behcets disease
Fuchs disease
HLA B27+
Pars planitis
Psoriatic arthritis
Reiters
Sarcoidosis
SLE
Birdshot
Rheumatoid arthritis
VKH
What are three common causes of uveitis in geriatric individuals?
Temporal arteritis
Ischaemia
Leukaemia/lymphoma
What are four common causes of uveitis in males?
Ankylosing spondylitis
Behcets disease
Psoriatic arthritis
Reiters syndrome
What are four common causes of uveitis in females?
JIA
MS
Scleroderma
Sjogrens syndrome
SLE
Rheumatoid arthritis
What are four common causes of uveitis in white people?
Ankylosing spondylitis
Psoriatic arthritis
Reiters syndrome
Birdshot retinopathy
What are three common causes of uveitis in asians?
Behcets disease
VKH
TB
What is a common cause of uveitis in black people?
Sarcoidosis