DIPHENHYDRAMINE (BENADRYL)

Question 1

CLASS

Answer 1

ANTIHISTAMINE

Question 2

DESCRIPTION

Answer 2

PREVENTS THE PHYSIOLOGIC ACTIONS OF HISTAMINE BY BLOCKING HISTAMINE -1 (H1) AND HISTAMINE -2 (H2) RECEPTOR SITES

Question 3

ONSET AND DURATION

Answer 3

ONSET- MAX EFFECTS 1-3 HOURS
DURATION- 6-12 HOURS

Question 4

INDICATIONS

Answer 4

MODERATE TO SEVER ALERGIC REACTIONS
ANAPHYLAXIS
ACUTE EXTRAPYRAMIDAL

Question 5

CONTRADICTIONS

Answer 5

PT TAKING NONSELECTIVE MAO INHIBITORS
HYPERSENSITIVITY
NARROW ANGLE GLAUCOMA
NEWBORNS AND NURSING MOTHERS

Question 6

ADVERSE REACTIONS

Answer 6

DOSE-RELATED DROWSINESS
DISTURED COORDINATION
HYPOTENSION
PALPATATIONS
TACHYCARDIA AND BRADYCARDIA
THICKENING OF BRONCHIAL SECRETIONS
DRY MOUTH AND THROAT
PARADOXIAL EXCITEMENT IN CHILDREN

Question 7

DRUG INTERACTIONS

Answer 7

CNS DEPRESSANT MAY INCREASE DEPRESSANT EFFECTS
MAO INHIBITORS MAY PROLONG INTENSIFY ANTICHOLINERGIC EFFECTS OF ANTIHISTAMINES

Question 8

HOW DIPHENHYDRAMINE IS SUPPLIED

Answer 8

PARENTERAL- 10- AND 50- MG/ML VIALS

Question 9

DOSAGE AND ADMINISTRAION

Answer 9

1 MG/KG ( MAX DOSE 50 MG) IV/PO OR SLOW IV

Question 10

SPECIAL CONSIDERATIONS

Answer 10

PREGNANCY SAFTEY- CLASS C
USE CAUTION IN PT WITH CNS DEPRESSION OR LOWER RESPIRATORY TRACT DISEASE SUCH AS ASTHMA