DIC Flashcards
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What is Disseminated Intravascular Coagulopathy (DIC)?
DIC is an acquired coagulation disorder characterized by widespread activation of the haemostatic mechanisms
What is the pathophysiology of DIC?
DIC initially presents with thrombosis due to micro-thrombi
What are common causes of DIC?
Causes include sepsis
What are the clinical features of DIC?
Symptoms include extensive skin and mucosal bleeding
What investigations are used to diagnose DIC?
Key investigations include FBC
How is DIC treated?
Treatment focuses on addressing the underlying cause
What are the consequences of DIC?
Consequences include multiple organ dysfunction affecting the liver
What are the differential diagnoses of DIC?
Differentials include thrombotic thrombocytopenic purpura
What is the role of fresh frozen plasma in DIC management?
Fresh frozen plasma is used to replace consumed coagulation factors and support haemostasis.
What causes thrombosis in DIC?
Thrombosis is caused by the formation of occlusive micro-thrombi that lead to tissue ischemia
What preventive measures can reduce the risk of DIC?
Prevention focuses on managing conditions like sepsis
What is the importance of D-dimers in DIC diagnosis?
Elevated D-dimers indicate increased fibrin degradation
What is the key step in managing amniotic fluid embolism-associated DIC?
Management involves treating the embolism
What are the major risk factors for obstetric-related DIC?
Risk factors include abruptio placentae
